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DDR2 (gen)

С Википедије, слободне енциклопедије
(преусмерено са DDR2)
Diskoidin domen receptor familija, izoforma 2
Identifikatori
Simboli DDR2; MIG20a; NTRKR3; TKT; TYRO10
Vanjski ID OMIM: 191311 MGI: 1345277 HomoloGene: 68505 GeneCards: DDR2 Gene
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 4921 18214
Ensembl ENSG00000162733 ENSMUSG00000026674
UniProt Q16832 Q62371
RefSeq (mRNA) NM_001014796 NM_022563
RefSeq (protein) NP_001014796 NP_072075
Lokacija (UCSC) Chr 1:
160.87 - 161.02 Mb		 Chr 1:
171.81 - 171.95 Mb
PubMed pretraga [1] [2]

DDR2, ili CD167b (klaster diferencijacije 167b), je ljudski gen[1], koji je član broj 2 familije diskoidin domen receptora.

Receptor tirozin kinaze (RTK) igraju ključnu ulogu u komunikaciji ćelija sa njihovim mikro okruženjem. Ti molekuli su vezani za regulaciju ćelijskog rasta, diferencijacije i metabolizma. U više slučajeva biohemijski mehanizam kojim RTK sprovodi signal kroz membranu je pokazan da se sastoji od ligand indukovane oligomerizacije receptora, i naknadne intracelularna fosforilacije. Ova autofosforilacija dovodi do naknadne fosforilacije citosolnih proteina, kao i do asocijacije sa drugim molekulima koji su vezani za pleiotropske efekte transdukcije signala. RTK proteini imaju trojnu strukturu koja se sastoji od ekstracelularnog, transmembranskog, i citoplazmatičnog regiona. Ovaj gen kodira pripadnika nove RTK podklase sa različitim ekstracelularnim regionom koji okružuje domen sličan faktoru VIII. Alternativno spajanje (engl. splicing) ovog gena na 5' UTR dovodi do nekoliko transkript varijanti.[1]

Interakcije

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Demonstrirano je da DDR2 ima protein-protein interakciju sa SHC1.[2]

Reference

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  1. ^ а б „Entrez Gene: DDR2 discoidin domain receptor family, member 2”. 
  2. ^ Ikeda, Kazuo; Wang Li-Hsien; Torres Richard; Zhao Hong; Olaso Elvira; Eng Francis J; Labrador Pablo; Klein Rudiger; Lovett David; Yancopoulos George D; Friedman Scott L; Lin Hsin Chieh (2002). „Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen”. J. Biol. Chem. United States. 277 (21): 19206—12. ISSN 0021-9258. PMID 11884411. doi:10.1074/jbc.M201078200. 

Literatura

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Spoljašnje veze

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