DTDP-glukozna 4,6-dehidrataza
(преусмерено са DTDP-glukoza 4,6-dehidrataza)
| DTDP-glukozna 4,6-dehidrataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.46 | ||||||||
| CAS broj | 37259-54-4 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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DTDP-glukozna 4,6-dehidrataza (EC 4.2.1.46, timidin difosfoglukozna oksidoreduktaza, TDP-glukozna oksidoreduktaza, dTDP-glukozna 4,6-hidrolijaza, dTDP-glukoza 4,6-hidrolijaza (formira dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza)) je enzim sa sistematskim imenom dTDP-alfa-D-glukoza 4,6-hidrolijaza (formira dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- dTDP-alfa-D-glukoza dTDP-4-dehidro-6-dezoksi-alfa-D-glukoza + H2O
Za dejstvo ovog enzima je neophodan NAD+.
Reference
[уреди | уреди извор]- ^ Gilbert, J.M., Matsuhashi, M. and Strominger, J.L. (1965). „Thymidine diphosphate 4-acetamido-4,6-dideoxyhexoses. II. Purification and properties of thymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 240: 1305—1308. PMID 14284740.
- ^ Melo, A., Elliott, H. and Glaser, L. (1968). „The mechanism of 6-deoxyhexose synthesis. I. Intramolecular hydrogen transfer catalyzed by deoxythymidine diphosphate D-glucose oxidoreductase”. J. Biol. Chem. 243: 1467—1474. PMID 4869560.
- ^ Wang, S.-F. & Gabriel, O. (1969). „Biological mechanisms involved in the formation of deoxy sugars. V. Isolation and crystallization of thymidine diphosphate-D-glucose oxidoreductase from Escherichia coli B”. J. Biol. Chem. 244: 3430—3437. PMID 4307450.
- ^ Hegeman, A.D., Gross, J.W. and Frey, P.A. (2001). „Probing catalysis by Escherichia coli dTDP-glucose-4,6-dehydratase: identification and preliminary characterization of functional amino acid residues at the active site”. Biochemistry. 40: 6598—6610. PMID 11380254.
- ^ Gross, J.W., Hegeman, A.D., Gerratana, B. and Frey, P.A. (2001). „Dehydration is catalyzed by glutamate-136 and aspartic acid-135 active site residues in Escherichia coli dTDP-glucose 4,6-dehydratase”. Biochemistry. 40: 12497—12504. PMID 11601973.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- DTDP-glucose+4,6-dehydratase на US National Library of Medicine Medical Subject Headings (MeSH)
