GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza
(преусмерено са GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase)
| GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza | |||||||||
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| Identifikatori | |||||||||
| EC broj | 2.4.1.257 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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GDP-Man:Man2GlcNAc2-PP-dolihol alfa-1,6-manoziltransferaza (EC 2.4.1.257, GDP-Man:Man2GlcNAc2-PP-Dol alfa-1,6-manoziltransferaza, Alg2 manoziltransferaza, ALG2 (gen), GDP-Man:Man1GlcNAc2-PP-dolihol manoziltransferaza) je enzim sa sistematskim imenom GDP-D-manoza:D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol alfa-6-manoziltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GDP-D-manoza + D-Man-alfa-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol GDP + D-Man-alfa-(1->3)-[D-Man-alfa-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-difosfodolihol
Biosinteza of asparaginom vezanih glikoproteina koristi dolihil difosfat-vezani glikozilni donor.
Reference
[уреди | уреди извор]- ^ Kampf, M., Absmanner, B., Schwarz, M. and Lehle, L. (2009). „Biochemical characterization and membrane topology of Alg2 from Saccharomyces cerevisiae as a bifunctional α1,3- and 1,6-mannosyltransferase involved in lipid-linked oligosaccharide biosynthesis”. J. Biol. Chem. 284: 11900—11912. PMID 19282279.
- ^ O'Reilly, M.K., Zhang, G. and Imperiali, B. (2006). „In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis”. Biochemistry. 45: 9593—9603. PMID 16878994.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- GDP-Man:Man2GlcNAc2-PP-dolichol+alpha-1,6-mannosyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
