Hormon-senzitivna lipaza
(преусмерено са Hormon senzitivna lipaza)
| Hormon-senzitivna lipaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.79 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Hormon-senzitivna lipaza (EC 3.1.1.79, HSL) je enzim sa sistematskim imenom diacilglicerol acilhidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) diacilglicerol + H2O monoacilglicerol + karboksilat
- (2) triacilglicerol + H2O diacilglicerol + karboksilat
- (3) monoacilglicerol + H2O glicerol + karboksilat
Ovaj enzim je serinska hidrolaza.
Reference
[уреди | уреди извор]- ^ Holm, C., Osterlund, T., Laurell, H. and Contreras, J.A. (2000). „Molecular mechanisms regulating hormone-sensitive lipase and lipolysis”. Annu. Rev. Nutr. 20: 365—393. PMID 10940339.
- ^ Fredrikson, G., Stralfors, P., Nilsson, N.O. and Belfrage, P. (1981). „Hormone-sensitive lipase of rat adipose tissue. Purification and some properties”. J. Biol. Chem. 256: 6311—6320. PMID 7240206.
- ^ Vaughan, M., Berger, J.E. and Steinberg, D. (1964). „Hormone-sensitive lipase and monoglyceride lipase activities in adipose tissue”. J. Biol. Chem. 239: 401—409. PMID 14169138.
- ^ Østerlund, T., Danielsson, B., Degerman, E., Contreras, J.A., Edgren, G., Davis, R.C., Schotz, M.C. and Holm, C. (1996). „Domain-structure analysis of recombinant rat hormone-sensitive lipase”. Biochem. J. 319 ( Pt 2): 411—420. PMID 8912675.
- ^ Lee, F.T., Adams, J.B., Garton, A.J. and Yeaman, S.J. (1988). „Hormone-sensitive lipase is involved in the hydrolysis of lipoidal derivatives of estrogens and other steroid hormones”. Biochim. Biophys. Acta. 963: 258—264. PMID 3196730.
- ^ Wei, S., Lai, K., Patel, S., Piantedosi, R., Shen, H., Colantuoni, V., Kraemer, F.B. and Blaner, W.S. (1977). „Retinyl ester hydrolysis and retinol efflux from BFC-1β adipocytes”. J. Biol. Chem. 272: 14159—14165. PMID 9162045.
- ^ Tsujita, T., Ninomiya, H. and Okuda, H. (1989). „p-Nitrophenyl butyrate hydrolyzing activity of hormone-sensitive lipase from bovine adipose tissue”. J. Lipid Res. 30: 997—1004. PMID 2794798.
- ^ Yeaman, S.J. (2004). „Hormone-sensitive lipase - new roles for an old enzyme”. Biochem. J. 379: 11—22. PMID 14725507.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Hormone-sensitive+lipase на US National Library of Medicine Medical Subject Headings (MeSH)
