Purinska nukleozidaza
(преусмерено са IAG-NH)
| Purinska nukleozidaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.2.2.1 | ||||||||
| CAS broj | 9025-44-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Purinska nukleozidaza (EC 3.2.2.1, nukleozidaza, purin beta-ribozidaza, purin nukleozidna hidrolaza, purinska ribonukleozidaza, ribonukleozidna hidrolaza, nukleozidna hidrolaza, N-ribozil purinska ribohidrolaza, nukleozidaza g, N-D-ribozilpurinska ribohidrolaza, inozin-adenozin-guanozin preferentna nukleozidna hidrolaza, purin-specifična nukleozidna N-ribohidrolaza, IAG-nukleozidna hidrolaza, IAG-NH) je enzim sa sistematskim imenom purin-nukleozidna ribohidrolaza.[1][2][3][4][5][6][7][8] Ovaj enzim katalizuje sledeću hemijsku reakciju
- purinski nukleozid + H2O D-riboza + purinska baza
Enzim iz bakterije Ochrobactrum anthropi specifično katalizuje ireverzibilnu N-ribozidnu hidrolizu purinskih nukleozida.
Reference
[уреди | уреди извор]- ^ Heppel, L.A. & Hilmoe, R.J. (1952). „Phosphorolysis and hydrolysis of purine ribosides from yeast”. J. Biol. Chem. 198: 683—694. PMID 12999785.
- ^ Kalckar, H.M. (1951). „Biosynthetic aspects of nucleosides and nucleic acids”. Pubbl. Staz. Zool. (Napoli). 23: 87—103.
- ^ Takagi, Y. & Horecker, B.L. (1956). „Purification and properties of a bacterial riboside hydrolyase”. J. Biol. Chem. 225: 77—86. PMID 13416219.
- ^ Tarr, H.L.A. (1955). „Fish muscle riboside hydrolases”. Biochem. J. 59: 386—391. PMID 14363106.
- ^ Parkin, D.W. (1996). „Purine-specific nucleoside N-ribohydrolase from 'Trypanosoma brucei brucei. Purification, specificity, and kinetic mechanism”. J. Biol. Chem. 271: 21713—21719. PMID 8702965.
- ^ Ogawa, J., Takeda, S., Xie, S.X., Hatanaka, H., Ashikari, T., Amachi, T. and Shimizu, S. (2001). „Purification, characterization, and gene cloning of purine nucleosidase from Ochrobactrum anthropi”. Appl. Environ. Microbiol. 67: 1783—1787. PMID 11282633.
- ^ Versées, W., Decanniere, K., Van Holsbeke, E., Devroede, N. and Steyaert, J. (2002). „Enzyme-substrate interactions in the purine-specific nucleoside hydrolase from Trypanosoma vivax”. J. Biol. Chem. 277: 15938—15946. PMID 11854281.
- ^ Mazumder-Shivakumar, D. & Bruice, T.C. (2005). „Computational study of IAG-nucleoside hydrolase: determination of the preferred ground state conformation and the role of active site residues”. Biochemistry. 44: 7805—7817. PMID 15909995.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Purine+nucleosidase на US National Library of Medicine Medical Subject Headings (MeSH)
