Metizolam

Metizolam
IUPAC ime
	4-(2-hlorofenil)-2-etil-6H-tieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin
Klinički podaci
Opojna droga	Moderate
Način primene	Oralno, sublingualno, rektalno
Pravni status
Pravni status	UK: Kontrolisana materija kao psihoaktivna supstanca ; Ilegalna materija u Švedskoj;
Identifikatori
CAS broj	40054-68-0
PubChem	CID 12434325
Hemijski podaci
Formula	C16H13ClN4S
Molarna masa	328.82 g/mol
	SMILES ClC1=C(C=CC=C1)C3=NCC2=NN=C[N]2C4=C3C=C(S4)CC; ;
	InChI InChI=1S/C16H13ClN4S/c1-2-10-7-12-15(11-5-3-4-6-13(11)17)18-8-14-20-19-9-21(14)16(12)22-10/h3-7,9H,2,8H2,1H3; Key:NQSSWDKQLVBUQN-UHFFFAOYSA-N;

Metizolam (desmetiltizolam) je tienotriazolodiazepin. On je demetilisani analog blisko srodnog etizolama.^[1]^[2]^[3]^[4]^[5]^[6]

Pravni status

Nakon njegove prodaje kao dizajnirana droga,^[7] metizolam je klasifikovan kao kontrolisana supstanca u Švedskoj 26. januara 2016.^[8]

Vidi još

Reference

^ Weber, Karl-Heinz; Bauer, Adolf; Langbein, Adolf; Daniel, Helmut (1978-09-20). „Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine”. Justus Liebigs Annalen der Chemie. 1978 (8): 1257—1265. ISSN 1099-0690. doi:10.1002/jlac.197819780806 — преко Wiley Online Library.
^ Michio Nakanishi; Tetsuya Tahara; Kazuhiko Araki; Masami Shiroki (1975-09-09). „Patent US 3904641 - Triazolothienodiazepine compounds”.
^ „Patent EP 0776892 - Thienylazole compound and thienotriazolodiazepine compound”. Yoshitomi Pharmaceutical Industries, Ltd. 1997-06-04.
^ Minoru Moriwaki; Masao Abe; Hiroshi Mikashima; Tetsuya Tahara (1993-03-03). „Patent EP 0315698 - Thieno(triazolo)diazepine compounds and medicinal application of the same”. Yoshitomi Pharmaceutical Industries, Ltd.
^ Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (2016). „Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines – an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam”. Journal of Mass Spectrometry. ISSN 1096-9888. PMID 27535017. doi:10.1002/jms.3840 — преко Wiley Online Library.
^ Kintz, Pascal; Richeval, Camille; Jamey, Carole; Ameline, Alice; Allorge, Delphine; Gaulier, Jean-Michel; Raul, Jean-Sébastien (2016). „Detection of the designer benzodiazepine metizolam, in urine and preliminary data on its metabolism”. Drug Testing and Analysis. ISSN 1942-7611. PMID 27671107. doi:10.1002/dta.2099.
^ „Desmethyletizolam”. New Synthetic Drugs Database. Архивирано из оригинала 25. 06. 2016. г. Приступљено 01. 10. 2016.
^ „31 nya ämnen kan klassas som narkotika eller hälsofarlig vara”. Folkhälsomyndigheten. 2015.

[1] Weber, Karl-Heinz; Bauer, Adolf; Langbein, Adolf; Daniel, Helmut (1978-09-20). „Heteroaromaten mit anellierten Siebenringen, III. Umwandlung von Thienotriazolooxazepinen in Diazepine”. Justus Liebigs Annalen der Chemie. 1978 (8): 1257—1265. ISSN 1099-0690. doi:10.1002/jlac.197819780806 — преко Wiley Online Library.

[2] Michio Nakanishi; Tetsuya Tahara; Kazuhiko Araki; Masami Shiroki (1975-09-09). „Patent US 3904641 - Triazolothienodiazepine compounds”.

[3] „Patent EP 0776892 - Thienylazole compound and thienotriazolodiazepine compound”. Yoshitomi Pharmaceutical Industries, Ltd. 1997-06-04.

[4] Minoru Moriwaki; Masao Abe; Hiroshi Mikashima; Tetsuya Tahara (1993-03-03). „Patent EP 0315698 - Thieno(triazolo)diazepine compounds and medicinal application of the same”. Yoshitomi Pharmaceutical Industries, Ltd.

[5] Moosmann, Bjoern; Bisel, Philippe; Franz, Florian; Huppertz, Laura M.; Auwärter, Volker (2016). „Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines – an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam, and nitrazolam”. Journal of Mass Spectrometry. ISSN 1096-9888. PMID 27535017. doi:10.1002/jms.3840 — преко Wiley Online Library.

[6] Kintz, Pascal; Richeval, Camille; Jamey, Carole; Ameline, Alice; Allorge, Delphine; Gaulier, Jean-Michel; Raul, Jean-Sébastien (2016). „Detection of the designer benzodiazepine metizolam, in urine and preliminary data on its metabolism”. Drug Testing and Analysis. ISSN 1942-7611. PMID 27671107. doi:10.1002/dta.2099.

[7] „Desmethyletizolam”. New Synthetic Drugs Database. Архивирано из оригинала 25. 06. 2016. г. Приступљено 01. 10. 2016.

[8] „31 nya ämnen kan klassas som narkotika eller hälsofarlig vara”. Folkhälsomyndigheten. 2015.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]