Све-транс-ретинил-палмитатна хидролаза
| Sve-trans-retinil-palmitatna hidrolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.1.64 | ||||||||
| CAS broj | 106389-24-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Sve-trans-retinil-palmitatna hidrolaza (EC 3.1.1.64, sve-trans-retinil-palmitat hidrolaza, sve-trans-retinol izomeraza:hidrolaza, sve-trans-retinilestar 11-cis izomerohidrolaza, RPE65 (gen)) je enzim sa sistematskim imenom sve-trans-retinil estar acilhidrolaza, formira 11-cis retinol.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- sve-trans-retinil estar + H2O 11-cis-retinol + masna kiselina
Ovaj enzim, koji deluje u retinalnom pigmentnom epitelu (RPE), katalizuje razlaganje i izomerizaciju sve-trans-retinil masno kiselinskih estara do 11-cis-retinola.
Reference
[уреди | уреди извор]- ^ Blaner, W.S., Das, S.R., Gouras, P. and Flood, M.T. (1987). „Hydrolysis of 11-cis- and all-trans-retinyl palmitate by homogenates of human retinal epithelial cells”. J. Biol. Chem. 262: 53—58. PMID 3793734.
- ^ Bernstein, P.S., Law, W.C. and Rando, R.R. (1987). „Isomerization of all-trans-retinoids to 11-cis-retinoids in vitro”. Proc. Natl. Acad. Sci. USA. 84: 1849—1853. PMID 3494246.
- ^ Bridges, C.D. & Alvarez, R.A. (1987). „The visual cycle operates via an isomerase acting on all-trans retinol in the pigment epithelium”. Science. 236: 1678—1680. PMID 3603006.
- ^ Moiseyev, G., Chen, Y., Takahashi, Y., Wu, B.X. and Ma, J.X. (2005). „RPE65 is the isomerohydrolase in the retinoid visual cycle”. Proc. Natl. Acad. Sci. USA. 102: 12413—12418. PMID 16116091.
- ^ Nikolaeva, O., Takahashi, Y., Moiseyev, G. and Ma, J.X. (2009). „Purified RPE65 shows isomerohydrolase activity after reassociation with a phospholipid membrane”. FEBS J. 276: 3020—3030. PMID 19490105.
- ^ Golczak, M., Kiser, P.D., Lodowski, D.T., Maeda, A. and Palczewski, K. (2010). „Importance of membrane structural integrity for RPE65 retinoid isomerization activity”. J. Biol. Chem. 285: 9667—9682. PMID 20100834.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Retinoid+isomerohydrolase на US National Library of Medicine Medical Subject Headings (MeSH)
