ТРНК псеудоуридинска55 синтаза
| TRNK pseudouridinska55 sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 5.4.99.25 | ||||||||
| CAS broj | 430429-15-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
TRNK pseudouridinska55 sintaza (EC 5.4.99.25, TruB, aCbf5, Pus4, YNL292w (gen), Psi55 tRNK pseudouridin sintaza, tRNK:Psi55-sintaza, tRNK pseudouridin 55 sintaza, tRNK:pseudouridin-55 sintaza, Psi55 sintaza, tRNK Psi55 sintaza, tRNK:Psi55 sintaza, tRNK-uridin55 uracil mutaza, Pus10, tRNK-uridin54/55 uracil mutaza) je enzim sa sistematskim imenom tRNK-uridin55 uracil mutaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- tRNK uridin55 tRNK pseudouridin55
Pseudouridinska sintaza TruB iz Escherichia coli specifično modifikuje uridin55 u tRNK molekulima.
Reference
[уреди | уреди извор]- ^ Nurse, K., Wrzesinski, J., Bakin, A., Lane, B.G. and Ofengand, J. (1995). „Purification, cloning, and properties of the tRNA Ψ55 synthase from Escherichia coli”. RNA. 1: 102—112. PMID 7489483.
- ^ Becker, H.F., Motorin, Y., Planta, R.J. and Grosjean, H. (1997). „The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of Ψ55 in both mitochondrial and cytoplasmic tRNAs”. Nucleic Acids Res. 25: 4493—4499. PMID 9358157.
- ^ Pienkowska, J., Wrzesinski, J. and Szweykowska-Kulinska, Z. (1998). „A cell-free yellow lupin extract containing activities of pseudouridine 35 and 55 synthases”. Acta Biochim. Pol. 45: 745—754. PMID 9918501.
- ^ Chaudhuri, B.N., Chan, S., Perry, L.J. and Yeates, T.O. (2004). „Crystal structure of the apo forms of Ψ55 tRNA pseudouridine synthase from Mycobacterium tuberculosis: a hinge at the base of the catalytic cleft”. J. Biol. Chem. 279: 24585—24591. PMID 15028724.
- ^ Hoang, C., Hamilton, C.S., Mueller, E.G. and Ferre-D'Amare, A.R. (2005). „Precursor complex structure of pseudouridine synthase TruB suggests coupling of active site perturbations to an RNA-sequestering peripheral protein domain”. Protein Sci. 14: 2201—2206. PMID 15987897.
- ^ Gurha, P. & Gupta, R. (2008). „Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA”. RNA. 14: 2521—2527. PMID 18952823.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- TRNA+pseudouridine55+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
