Триазолам

Триазолам
Klinički podaci
Prodajno ime	Alti-Triazolam, Apo-Triazo, Clorazolam, Gen-Triazolam
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	1,5-5,5 h
Identifikatori
CAS број	28911-01-5
ATC kod	N05CD05 (WHO)
PubChem	CID 5556
DrugBank	DB00897
ChemSpider	5355
ChEBI	CHEBI:9674
ChEMBL	CHEMBL646
Hemijski podaci
Formula	C17H12Cl2N4
Molarna masa	343,210
	SMILES CC1=NN=C2CN=C(C3=CC=CC=C3Cl)C3=C(C=CC(Cl)=C3)N12; ;
	InChI InChI=1S/C17H12Cl2N4/c1-10-21-22-16-9-20-17(12-4-2-3-5-14(12)19)13-8-11(18)6-7-15(13)23(10)16/h2-8H,9H2,1H3 ; Key:JOFWLTCLBGQGBO-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	233—235 °C (451—455 °F)

Triazolam je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 343,210 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	3
Broj donora vodonika	0
Broj rotacionih veza	1
Particioni koeficijent^[8] (ALogP)	4,2
Rastvorljivost^[9] (logS, log(mol/L))	-6,6
Polarna površina^[10] (PSA, Å²)	43,1

Reference

^ Rickels K. „The clinical use of hypnotics: indications for use and the need for a variety of hypnotics”. Acta Psychiatr Scand Suppl. 1986 (332): 132—41. PMID 2883820.
^ Oelschläger, H. (1989). „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.
^ Noguchi H, Kitazumi K, Mori M, Shiba T (март 2004). „Electroencephalographic properties of zaleplon, a non-benzodiazepine sedative/hypnotic, in rats”. J Pharmacol Sci. 94 (3): 246—51. PMID 15037809.
^ Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C (фебруар 2007). „Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats”. J Pharmacol Sci. 103 (2): 201—6. PMID 17287588.
^ Veje, J. O.; Andersen, K.; Gjesing, S.; Kielgast, H. (август 1989). „Prescription of tranquilizers and hypnotics in the municipality of Holbaek”. Ugeskr Laeger. 151 (34): 2134—6. PMID 2773144.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Triazolam

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Rickels K. „The clinical use of hypnotics: indications for use and the need for a variety of hypnotics”. Acta Psychiatr Scand Suppl. 1986 (332): 132—41. PMID 2883820.

[2] Oelschläger, H. (1989). „Chemical and pharmacologic aspects of benzodiazepines”. Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse de Medecine Praxis. 78 (27–28): 766—772. PMID 2570451.

[3] Noguchi H, Kitazumi K, Mori M, Shiba T (март 2004). „Electroencephalographic properties of zaleplon, a non-benzodiazepine sedative/hypnotic, in rats”. J Pharmacol Sci. 94 (3): 246—51. PMID 15037809.

[4] Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C (фебруар 2007). „Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats”. J Pharmacol Sci. 103 (2): 201—6. PMID 17287588.

[5] Veje, J. O.; Andersen, K.; Gjesing, S.; Kielgast, H. (август 1989). „Prescription of tranquilizers and hypnotics in the municipality of Holbaek”. Ugeskr Laeger. 151 (34): 2134—6. PMID 2773144.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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