2,4-diaminopentanoat dehidrogenaza
Appearance
2,4-diaminopentanoat dehidrogenaza | |||||||||
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Identifikatori | |||||||||
EC broj | 1.4.1.12 | ||||||||
CAS broj | 39346-26-4 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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2,4-diaminopentanoat dehidrogenaza (EC 1.4.1.12, 2,4-diaminopentanoatna kiselina C4 dehidrogenaza) je enzim sa sistematskim imenom 2,4-diaminopentanoat:NAD(P)+ oksidoreduktaza (deaminacija).[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 2,4-diaminopentanoat +H2O + NAD(P)+ 2-amino-4-oksopentanoat + NH3 + NAD(P)H + H+
Ovaj enzim takođe deluje, mada sporo, na 2,5-diaminoheksanoat i formira 2-amino-5-oksoheksanoat.
Reference[uredi | uredi izvor]
- ^ Somack, R. & Costilow, R.N. (1973). „2,4-Diaminopentanoic acid C4 dehydrogenase. Purification and properties of the protein”. J. Biol. Chem. 248: 385—388. PMID 4684685.
- ^ Stadtman, T.C. (1973). „Lysine metabolism by clostridia. XIIB 2,4-Diaminohexanoate dehydrogenase (2,4-diaminopentanoate dehydrogenase)”. Adv. Enzymol. Relat. Areas Mol. Biol. 38: 441—445.
- ^ Tsuda, Y. & Friedmann, H.C. (1970). „Ornithine metabolism by Clostridium sticklandii. Oxidation of ornithine to 2-amino-4-ketopentanoic acid via 2,4-diaminopentanoic acid; participation of B12 coenzyme, pyridoxal phosphate, and pyridine nucleotide”. J. Biol. Chem. 245: 5914—5926. PMID 4394942.
Literatura[uredi | uredi izvor]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[uredi | uredi izvor]
- 2,4-diaminopentanoate+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)