Akrilna kiselina

Akrilna kiselina
Identifikacija
CAS broj	79-10-7 ;
3D model (Jmol)	interaktivna slika;
ChEBI	CHEBI:18308 ;
ChemSpider	6333 ;
DrugBank	DB02579;
ECHA InfoCard	100.001.071
KEGG	C00511 ;
PubChem C ID	6581;
	SMILES OC(=O)C=C; ; ; ; ; ;
Svojstva
Hemijska formula	C3H4O2
Molarna masa	72,063
Tačka topljenja	13.5
Tačka ključanja	141.2 °C
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	verifikuj (šta je ?)
	Reference infokutije

Akrilna kiselina je organsko jedinjenje, koje sadrži 3 atoma ugljenika i ima molekulsku masu od 72,063 Da.^[4]^[5]

Hemijska formula akrilne kiseline je CH₂=CHCOOH. To je najjednostavnija nezasićena karboksilna kiselina, koja sadrži vinil grupu direktno vezanu za funkcionalnu grupu karboksilnih kiselina. Akrilna kiselina je bezbojna tečnost oštrog karakterističnog mirisa. Rastvorljiva je u vodi, alkoholu, etrima i hloroformu. Na globalnom nivou, godišnje se proizvede više od hiljadu kilotona akrilne kiseline, većinom za potrebe flokulanata i emulgatora.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	1
Broj rotacionih veza	1
Particioni koeficijent^[6] (ALogP)	0,5
Rastvorljivost^[7] (logS, log(mol/L))	-0,3
Polarna površina^[8] (PSA, Å²)	37,3

Reference

^ Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. uredi
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Nucleic Acids Res (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. |first2= zahteva |last2= u Authors list (pomoć); |first3= zahteva |last3= u Authors list (pomoć); |first4= zahteva |last4= u Authors list (pomoć); |first5= zahteva |last5= u Authors list (pomoć); |first6= zahteva |last6= u Authors list (pomoć); |first7= zahteva |last7= u Authors list (pomoć); |first8= zahteva |last8= u Authors list (pomoć)
^ Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. Arhivirano iz originala 22. 07. 2014. g. Pristupljeno 13. 12. 2013.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Clayden, Jonathan; Greeves, Nick; Warren, Stuart; Wothers, Peter (2001). Organic Chemistry (I izd.). Oxford University Press. ISBN 978-0-19-850346-0.
Smith, Michael B.; March, Jerry (2007). Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th izd.). New York: Wiley-Interscience. ISBN 0-471-72091-7.
Katritzky A.R.; Pozharskii A.F. (2000). Handbook of Heterocyclic Chemistry (Second izd.). Academic Press. ISBN 0080429882.

Spoljašnje veze

Acrylic acid

[1] Joanne Wixon; Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast. 17 (1): 48—55. doi:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.

[2] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. uredi

[3] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[4] Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Nucleic Acids Res (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. |first2= zahteva |last2= u Authors list (pomoć); |first3= zahteva |last3= u Authors list (pomoć); |first4= zahteva |last4= u Authors list (pomoć); |first5= zahteva |last5= u Authors list (pomoć); |first6= zahteva |last6= u Authors list (pomoć); |first7= zahteva |last7= u Authors list (pomoć); |first8= zahteva |last8= u Authors list (pomoć)

[6] Ghose, A.K., Viswanadhan V.N., and Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o. Arhivirano iz originala 22. 07. 2014. g. Pristupljeno 13. 12. 2013.

[7] Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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Normativna kontrola
Državne	Nemačka Izrael Sjedinjene Države Japan
Ostale	Enciklopedija Britanika