CHST5

CHST5
Identifikatori
Alijasi	CHST5
Spoljašnji ID	OMIM: 604817 HomoloGene: 69379 GeneCards: CHST5
Obrazac RNK izražavanja
	More reference expression data
Genska ontologija
Molecular function	• transferase activity; • sulfotransferase activity; • N-acetylglucosamine 6-O-sulfotransferase activity;
Cellular component	• Golgi membrane; • Goldžijev aparat; • intrinsic component of Golgi membrane; • membrana; • sastavni deo membrane; • trans-Golgi network;
Biological process	• sulfur compound metabolic process; • protein sulfation; • keratan sulfate biosynthetic process; • N-acetylglucosamine metabolic process; • Metabolizam ugljenih hidrata;
	Sources:Amigo / QuickGO
Ortolozi
	23563
	n/a
	ENSG00000135702
	n/a
	Q9GZS9
	n/a
	NM_024533; NM_012126
	n/a
	NP_078809
	n/a
	Wikidata
View/Edit Human

Ugljeno hidratna sulfotransferaza 5 (eng. Carbohydrate sulfotransferase 5) je enzim koji je kod ljudi kodiran istoimenim genom CHST5^[2]^[3]^[4] , nalazi se na kratkom kraku 16 hromozoma.^[5] Dužina polipeptidnog lanca je 411 aminokiselina, a molekulska težina 46.161.^[6]

Reference

^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lee JK, Bhakta S, Rosen SD, Hemmerich S (septembar 1999). „Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue”. Biochemical and Biophysical Research Communications. 263 (2): 543—9. PMID 10491328. doi:10.1006/bbrc.1999.1324. CS1 održavanje: Format datuma (veza)
^ Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (oktobar 2000). „Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene”. Nature Genetics. 26 (2): 237—41. PMID 11017086. S2CID 25547752. doi:10.1038/79987. CS1 održavanje: Format datuma (veza)
^ „Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5”.
^ „HUGO Gene Nomenclature Commitee, HGNC:1971” (na jeziku: eng.). Pristupljeno 19. 09. 2017. ^{[mrtva veza]}
^ „UniProt, Q9GZS9” (na jeziku: eng.). Arhivirano iz originala 1. 1. 2017. g. Pristupljeno 07. 06. 2024.

Literatura

Bernstein HB, Compans RW (decembar 1992). „Sulfation of the human immunodeficiency virus envelope glycoprotein”. Journal of Virology. 66 (12): 6953—9. PMC 240329 . PMID 1433500. doi:10.1128/JVI.66.12.6953-6959.1992. CS1 održavanje: Format datuma (veza)
Shilatifard A, Merkle RK, Helland DE, Welles JL, Haseltine WA, Cummings RD (februar 1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine”. Journal of Virology. 67 (2): 943—52. PMC 237448 . PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993. CS1 održavanje: Format datuma (veza)
Bartes A, Bhakta S, Hemmerich S (april 2001). „Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta)”. Biochemical and Biophysical Research Communications. 282 (4): 928—33. PMID 11352640. doi:10.1006/bbrc.2001.4668. CS1 održavanje: Format datuma (veza)
Seko A, Nagata K, Yonezawa S, Yamashita K (jun 2002). „Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma”. Glycobiology. 12 (6): 379—88. PMID 12107080. doi:10.1093/glycob/12.6.379 . CS1 održavanje: Format datuma (veza)
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (novembar 2002). „Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate”. The Journal of Biological Chemistry. 277 (45): 42505—13. PMID 12218059. doi:10.1074/jbc.M207412200 . CS1 održavanje: Format datuma (veza)
Lee JK, Bistrup A, van Zante A, Rosen SD (april 2003). „Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications”. Glycobiology. 13 (4): 245—54. PMID 12626414. doi:10.1093/glycob/cwg018. CS1 održavanje: Format datuma (veza)
de Graffenried CL, Bertozzi CR (oktobar 2003). „Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis”. The Journal of Biological Chemistry. 278 (41): 40282—95. PMID 12855678. doi:10.1074/jbc.M304928200 . CS1 održavanje: Format datuma (veza)
Kitayama K, Hayashida Y, Nishida K, Akama TO (oktobar 2007). „Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans”. The Journal of Biological Chemistry. 282 (41): 30085—96. PMID 17690104. doi:10.1074/jbc.M703695200 . CS1 održavanje: Format datuma (veza)

[1] „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10491328-2] Lee JK, Bhakta S, Rosen SD, Hemmerich S (septembar 1999). „Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue”. Biochemical and Biophysical Research Communications. 263 (2): 543—9. PMID 10491328. doi:10.1006/bbrc.1999.1324. CS1 održavanje: Format datuma (veza)

[pmid11017086-3] Akama TO, Nishida K, Nakayama J, Watanabe H, Ozaki K, Nakamura T, Dota A, Kawasaki S, Inoue Y, Maeda N, Yamamoto S, Fujiwara T, Thonar EJ, Shimomura Y, Kinoshita S, Tanigami A, Fukuda MN (oktobar 2000). „Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene”. Nature Genetics. 26 (2): 237—41. PMID 11017086. S2CID 25547752. doi:10.1038/79987. CS1 održavanje: Format datuma (veza)

[entrez-4] „Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5”.

[HGNC-5] „HUGO Gene Nomenclature Commitee, HGNC:1971” (na jeziku: eng.). Pristupljeno 19. 09. 2017. ^{[mrtva veza]}

[UniProt-6] „UniProt, Q9GZS9” (na jeziku: eng.). Arhivirano iz originala 1. 1. 2017. g. Pristupljeno 07. 06. 2024.

[1]

[2]

[3]

[4]

[5]

[6]

p r u Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6