Шаблон:Metadon na opioidnim receptorima, monoaminskim transporterima i NMDA receptorima-lat
Изглед
Jedinjenje | Afiniteti (Ki, in nM) | Odnosi | ||||||
---|---|---|---|---|---|---|---|---|
MOR | DOR | KOR | SERT | NET | NMDAR | M:D:K | SERT:NET | |
Racemski metadon | 1,7 | 435 | 405 | 1.400 | 259 | 2.500–8.300 | 1:256:238 | 1:5 |
Dekstrometadon | 19,7 | 960 | 1.370 | 992 | 12.700 | 2.600–7.400 | 1:49:70 | 1:13 |
Levometadon | 0,945 | 371 | 1.860 | 14,1 | 702 | 2.800–3.400 | 1:393:1968 | 1:50 |
Документација шаблона
References
- ^ Codd EE, Shank RP, Schupsky JJ, Raffa RB (1995). „Serotonin and norepinephrine uptake inhibiting activity of centrally acting analgesics: structural determinants and role in antinociception”. J. Pharmacol. Exp. Ther. 274 (3): 1263—70. PMID 7562497.
- ^ Gorman AL, Elliott KJ, Inturrisi CE (фебруар 1997). „The d- and l-isomers of methadone bind to the non-competitive site on the N-methyl-D-aspartate (NMDA) receptor in rat forebrain and spinal cord”. Neurosci. Lett. 223 (1): 5—8. PMID 9058409. doi:10.1016/S0304-3940(97)13391-2.