(-)-Germakrenska D sintaza
| (-)-Germakrenska D sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.75 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
(-)-Germakrenska D sintaza (EC 4.2.3.75, (-)-germacrene D synthase) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (-)-germakren-D).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat (-)-germakren D + difosfat
U Solidago canadensis ova biosinteza proizvodi pro-R vodonik u C-1 farnezil difosfata.
Reference
[уреди | уреди извор]- ^ Schmidt, C.O.; Bouwmeester, H.J.; Franke, S.; König, W.A. (1999). „Mechanisms of the biosynthesis of sesquiterpene enantiomers (+)- and (-)-germacrene D in Solidago canadensis”. Chirality. 11: 353—362.
- ^ He, X. & Cane, D.E. (2004). „Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2)”. J. Am. Chem. Soc. 126: 2678—2679. PMID 14995166.
- ^ Lucker, J.; Bowen, P.; Bohlmann, J. (2004). „Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries”. Phytochemistry. 65: 2649—2659. PMID 15464152.
- ^ Prosser, I.; Altug, I.G.; Phillips, A.L.; Konig, W.A.; Bouwmeester, H.J.; Beale, M.H. (2004). „Enantiospecific (+)- and (-)-germacrene D synthases, cloned from goldenrod, reveal a functionally active variant of the universal isoprenoid-biosynthesis aspartate-rich motif”. Arch. Biochem. Biophys. 432: 136—144. PMID 15542052.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- (-)-germacrene+D+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
