UDP-N-acetilglukozamin kinaza
| UDP-N-acetilglukozamin kinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.7.1.176 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
UDP-N-acetilglukozamin kinaza (EC 2.7.1.176, UNAG kinaza, zeta toksin, toksin PezT, ATP:UDP-N-acetil-D-glukozaminska 3'-fosfotransferaza) je enzim sa sistematskim imenom ATP:UDP-N-acetil-alfa-D-glukozamin 3'-fosfotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj protein je toksična komponenta toksin-antitoksin (TA) modula. Fosforilacija UDP-N-acetil-D-glukozamina dovodi do inhibicije EC 2.5.1.7, UDP-N-acetilglukozamin 1-karboksiviniltransferaze.
Reference
[уреди | уреди извор]- ^ Khoo, S.K., Loll, B., Chan, W.T., Shoeman, R.L., Ngoo, L., Yeo, C.C. and Meinhart, A. (2007). „Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae”. J. Biol. Chem. 282: 19606—19618. PMID 17488720.
- ^ Mutschler, H., Gebhardt, M., Shoeman, R.L. and Meinhart, A. (2011). „A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis”. PLoS Biol. 9: #e1001033—e1001033. PMID 21445328.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- UDP-N-acetylglucosamine+kinase на US National Library of Medicine Medical Subject Headings (MeSH)
