3-Dezoksi-8-fosfooktulonat sintaza

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PMC	članci
PubMed	članci
NCBI	proteini

3-Dezoksi-8-fosfooktulonat sintaza
3-Dezoksi-8-fosfooktulonat sintaza
Identifikatori
EC broj	2.5.1.55
CAS broj	9026-96-4
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

3-Dezoksi-8-fosfooktulonat sintaza (EC 2.5.1.55, 2-dehidro-3-dezoksi-D-oktonat-8-fosfat D-arabinoza-5-fosfat-lijaza (piruvatna fosforilacija), 2-dehidro-3-dezoksi-fosfooktonat aldolaza, 2-keto-3-dezoksi-8-fosfooktonska sintetaza, 3-dezoksi-D-mano-oktulozonat-8-fosfatna sintaza, 3-dezoksi-D-manooktulozonat-8-fosfat sintetaza, 3-dezoksioktulozonska 8-fosfat sintetaza, KDOP sintaza, fosfo-2-keto-3-dezoksioktonat aldolaza) je enzim sa sistematskim imenom fosfoenolpiruvat:D-arabinoza-5-fosfat C-(1-karboksivinil)transferaza (fosfatna hidroliza, formira 2-karboksi-2-oksoetil).^[1]^[2]^[3] Ovaj enzim katalizuje sledeću hemijsku reakciju

fosfoenolpiruvat + D-arabinoza 5-fosfat + H ₂O

\rightleftharpoons

2-dehidro-3-dezoksi-D-oktonat 8-fosfat + fosfat

Reference

^ Levin, D.H. & Racker, E. (1959). „Condensation of arabinose 5-phosphate and phosphorylenol pyruvate by 2-keto-3-deoxy-8-phosphooctonic acid synthetase”. J. Biol. Chem. 234: 2532—25339. PMID 14416200.
^ Krosky, D.J., Alm, R., Berg, M., Carmel, G., Tummino, P.J., Xu, B. and Yang, W. (2002). „Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme”. Biochim. Biophys. Acta. 1594: 297—306. PMID 11904225.
^ Asojo, O., Friedman, J., Adir, N., Belakhov, V., Shoham, Y. and Baasov, T. (2001). „Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor”. Biochemistry. 40: 6326—6334. PMID 11371194.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

3-deoxy-8-phosphooctulonate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Levin, D.H. & Racker, E. (1959). „Condensation of arabinose 5-phosphate and phosphorylenol pyruvate by 2-keto-3-deoxy-8-phosphooctonic acid synthetase”. J. Biol. Chem. 234: 2532—25339. PMID 14416200.

[2] Krosky, D.J., Alm, R., Berg, M., Carmel, G., Tummino, P.J., Xu, B. and Yang, W. (2002). „Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate (KDO-8-P) synthase is a zinc-metalloenzyme”. Biochim. Biophys. Acta. 1594: 297—306. PMID 11904225.

[3] Asojo, O., Friedman, J., Adir, N., Belakhov, V., Shoham, Y. and Baasov, T. (2001). „Crystal structures of KDOP synthase in its binary complexes with the substrate phosphoenolpyruvate and with a mechanism-based inhibitor”. Biochemistry. 40: 6326—6334. PMID 11371194.

[1]

[2]

[3]

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6