3a(or 20b)-hidroksisteroid dehidrogenaza
| 3a(or 20b)-hidroksisteroid dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.1.1.53 | ||||||||
| CAS broj | 9028-42-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
3a(or 20b)-hidroksisteroid dehidrogenaza (EC 1.1.1.53, kortizon reduktaza, (R)-20-hidroksisteroid dehidrogenaza, dehidrogenaza, 20beta-hidroksi steroid, Delta4-3-ketosteroid hidrogenaza, 20beta-hidroksisteroid dehidrogenaza, 3alfa,20beta-hidroksisteroid:NAD+-oksidoreduktaza, NADH-20beta-hidroksisteroid dehidrogenaza, 20beta-HSD) je enzim sa sistematskim imenom 3alfa(or 20beta)-hidroksisteroid:NAD+ oksidoreduktaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- androstaN-3alfa,17beta-diol + NAD+ 17beta-hidroksiandrostaN-3-on + NADH + H+
3alfa-hidroksi grupa ili 20beta-hidroksi grupa pregnana i androstanskih steroida mogu da deluju kao donori.
Reference
[уреди | уреди извор]- ^ Edwards, C.A.F. & Orr, J.C. (1978). „Comparison of the 3α-and 20β-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans”. Biochemistry. 17: 4370—4376. PMID 718844.
- ^ Hübener, H.J. & Sahrholz, F.G. (1960). „20β-hydroxy-steroid-dehydrogenase. II. Darstellung und Kristallisation”. Biochem. Z. 333: 95—105. PMID 14403761.
- ^ Hübener, H.J., Sahrholz, F.G., Schmidt-Thomé, J., Nesemann, G. and Junk, R. (1959). „20β-Hydroxy-Steroid-Dehydrogenase, ein neues kristallines Enzym”. Biochim. Biophys. Acta. 35: 270—272. PMID 14403760.
- ^ Lynn, W.S. & Brown, R.H. (1958). „The conversion of progesterone to androgens by testes”. J. Biol. Chem. 232: 1015—1030. PMID 13549484.
- ^ Strickler, R.C., Covey, D.F. and Tobias, B. (1980). „Study of 3α, 20 β-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site”. Biochemistry. 19: 4950—4954. PMID 6936053.
- ^ Sweet, F. & Samant, B.S. (1980). „Bifunctional enzyme activity at the same active site: study of 3α and 20β activity by affinity alkylation of 3α, 20β-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids”. Biochemistry. 19: 978—986. PMID 6928375.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 3alpha(or+20beta)-hydroxysteroid+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
