Naftoatna sintaza
(преусмерено са 4-(2-karboksifenil)-4-oksobutanoil-KoA dehidrataza (ciklizacija))
| Naftoatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Naftoatna sintaza hexamer, Mycobacterium tuberculosis | |||||||||
| Identifikatori | |||||||||
| EC broj | 4.1.3.36 | ||||||||
| CAS broj | 61328-42-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Naftoatna sintaza (EC 4.1.3.36, 1,4-dihidroksi-2-naftoatna sintaza, dihidroksinaftoatna sintaza, o-sukcinilbenzoil-KoA 1,4-dihidroksi-2-naftoatna-lijaza (ciklizacija), MenB, o-sukcinilbenzoil-KoA dehidrataza (ciklizacija)) je enzim sa sistematskim imenom 4-(2-karboksifenil)-4-oksobutanoil-KoA dehidrataza (ciklizacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-(2-karboksifenil)-4-oksobutanoil-KoA 1,4-dihidroksi-2-naftoil-KoA + H2O
Ovaj enzim učestvuje u sintezi 1,4-dihidroksi-2-naftoata.
Reference
[уреди | уреди извор]- ^ Meganathan, R. & Bentley, R. (1979). „Menaquinone (vitamin K2) biosynthesis: conversion of o-succinylbenzoic acid to 1,4-dihydroxy-2-naphthoic acid by Mycobacterium phlei enzymes”. J. Bacteriol. 140: 92—98. PMID 500558.
- ^ Kolkmann, R. & Leistner, E. (1987). „4-(2′-Carboxyphenyl)-4-oxobutyryl coenzyme A ester, an intermediate in vitamin K2 (menaquinone) biosynthesis”. Z. Naturforsch. C: Sci. 42: 1207—1214. PMID 2966501.
- ^ Johnson, T.W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I.R., Bryant, D.A., Jones, A.D., Golbeck, J.H. and Chitnis, P.R. (2000). „Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803”. J. Biol. Chem. 275: 8523—8530. PMID 10722690.
- ^ Truglio, J.J., Theis, K., Feng, Y., Gajda, R., Machutta, C., Tonge, P.J. and Kisker, C. (2003). „Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis”. J. Biol. Chem. 278: 42352—42360. PMID 12909628.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- 1,4-dihydroxy-2-naphthoyl-CoA+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
