5-Epiaristolohenska sintaza
| 5-Epiaristolohenska sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.3.61 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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5-Epiaristolohenska sintaza (EC 4.2.3.61, 5-epi-aristolohenska sintaza, tobako epiaristolohenska sintaza, farnezil pirofosfatna ciklaza, EAS, TEAS) je enzim sa sistematskim imenom (2E,6E)-farnezil-difosfat difosfat-lijaza (formira (+)-5-epiaristolohen).[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (2E,6E)-farnezil difosfat (+)-5-epiaristolohen + difosfat
Inicijalna ciklizacija daje (+)-germakren A koji je vezan za enzim.
Reference
[уреди | уреди извор]- ^ Back, K., Yin, S. and Chappell, J. (1994). „Expression of a plant sesquiterpene cyclase gene in Escherichia coli”. Arch. Biochem. Biophys. 315: 527—532. PMID 7986100.
- ^ Starks, C.M., Back, K., Chappell, J. and Noel, J.P. (1997). „Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase”. Science. 277: 1815—1820. PMID 9295271.
- ^ Back, K., He, S., Kim, K.U. and Shin, D.H. (1998). „Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in UV-challenged leaves of Capsicum annuum”. Plant Cell Physiol. 39: 899—904. PMID 9816674.
- ^ Rising, K.A., Starks, C.M., Noel, J.P. and Chappell, J. (2000). „Demonstration of germacrene A as an intermediate in 5-epi-aristolochene synthase catalysis”. J. Am. Chem. Soc. 122: 1861—1866.
- ^ Bohlmann, J., Stauber, E.J., Krock, B., Oldham, N.J., Gershenzon, J. and Baldwin, I.T. (2002). „Gene expression of 5-epi-aristolochene synthase and formation of capsidiol in roots of Nicotiana attenuata and N. sylvestris'”. Phytochemistry. 60: 109—116. PMID 12009313.
- ^ O'Maille, P.E., Chappell, J. and Noel, J.P. (2006). „Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase”. Arch. Biochem. Biophys. 448: 73—82. PMID 16375847.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 5-epiaristolochene+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
