Bornil difosfatna sintaza
Изглед
Bornil difosfatna sintaza | |||||||||
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Identifikatori | |||||||||
EC broj | 5.5.1.8 | ||||||||
CAS broj | 72668-91-8 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Bornil difosfatna sintaza (EC 5.5.1.8, bornil pirofosfatna sintaza, bornil pirofosfatna sintetaza, (+)-bornilpirofosfatna ciklaza, geranil-difosfatna ciklaza) je enzim sa sistematskim imenom (+)-bornil-difosfat lijaza (deciklizacija).[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- geranil difosfat (+)-bornil difosfat
Za dejstvo ovog enzima je neophodan jon Mn2+.
Reference
[уреди | уреди извор]- ^ Croteau, R. & Karp, F. (1979). „Biosynthesis of monoterpenes: preliminary characterization of bornyl pyrophosphate synthetase from sage (Salvia officinalis) and demonstration that geranyl pyrophosphate is the preferred substrate for cyclization”. Arch. Biochem. Biophys. 198: 512—522. PMID 42356.
- ^ Croteau, R., Gershenzon, J., Wheeler, C.J. and Satterwhite, D.M. (1990). „Biosynthesis of monoterpenes: stereochemistry of the coupled isomerization and cyclization of geranyl pyrophosphate to camphane and isocamphane monoterpenes”. Arch. Biochem. Biophys. 277: 374—381. PMID 2178556.
- ^ Croteau, R., Satterwhite, D.M., Cane, D.E. and Chang, C.C. (1986). „Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (-)-linalyl pyrophosphate to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 261: 13438—13445. PMID 3759972.
- ^ Croteau, R., Felton, N.M. and Wheeler, C.J. (1985). „Stereochemistry at C-1 of geranyl pyrophosphate and neryl pyrophosphate in the cyclization to (+)- and (-)-bornyl pyrophosphate”. J. Biol. Chem. 260: 5956—5962. PMID 3997807.
- ^ Croteau, R.B., Shaskus, J.J., Renstrom, B., Felton, N.M., Cane, D.E., Saito, A. and Chang, C. (1985). „Mechanism of the pyrophosphate migration in the enzymatic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates”. Biochemistry. 24: 7077—7085. PMID 4084562.
- ^ McGeady, P. & Croteau, R. (1995). „Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor”. Arch. Biochem. Biophys. 317: 149—155. PMID 7872777.
- ^ Wise, M.L., Savage, T.J., Katahira, E. and Croteau, R. (1998). „Monoterpene synthases from common sage (Salvia officinalis). cDNA isolation, characterization, and functional expression of (+)-sabinene synthase, 1,8-cineole synthase, and (+)-bornyl diphosphate synthase”. J. Biol. Chem. 273: 14891—14899. PMID 9614092.
- ^ Whittington, D.A., Wise, M.L., Urbansky, M., Coates, R.M., Croteau, R.B. and Christianson, D.W. (2002). „Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase”. Proc. Natl. Acad. Sci. USA. 99: 15375—15380. PMID 12432096.
- ^ Peters, R.J. & Croteau, R.B. (2003). „Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases”. Arch. Biochem. Biophys. 417: 203—211. PMID 12941302.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- (+)-bornyl+diphosphate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)