CHST6

CHST6
Identifikatori
Alijasi	CHST6
Spoljašnji ID	OMIM: 605294 MGI: 1931825 HomoloGene: 56927 GeneCards: CHST6
Genska lokacija (miš) Hr. Chromosome 8 (mouse) Band 8|8 E1 Start 112,615,768 bp Kraj 112,637,079 bp
Genska ontologija Molecular function • sulfotransferase activity • transferase activity • N-acetylglucosamine 6-O-sulfotransferase activity Cellular component • Голџијев апарат • Golgi membrane • мембрана • саставни део мембране • trans-Golgi network Biological process • sulfur compound metabolic process • keratan sulfate biosynthetic process • N-acetylglucosamine metabolic process • Метаболизам угљених хидрата Sources:Amigo / QuickGO
Ortolozi
Vrste	Čovek	Miš
Entrez	4166	56773
Ensembl	ENSG00000183196	ENSMUSG00000031952
UniProt	Q9GZX3	Q9QUP4
RefSeq (mRNA)	NM_021615	NM_019950
RefSeq (protein)	NP_067628	NP_064334
Location (UCSC)	n/a	Chr 8: 112.62 – 112.64 Mb
PubMed search
Wikidata
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Ugljeno hidratna sulfotransferaza 6 (eng. Carbohydrate sulfotransferase 6) je enzim koji je kod ljudi kodiran istoimenim genom CHST6 , nalazi se na kratkom kraku 16 hromozoma. Dužina polipeptidnog lanca je 395 aminokiselina, a molekulska težina 44.099.

Literatura

• Bernstein HB, Compans RW (1992). „Sulfation of the human immunodeficiency virus envelope glycoprotein.”. J. Virol. 66 (12): 6953—9. PMC 240329 . PMID 1433500. doi:10.1128/JVI.66.12.6953-6959.1992. 
• Shilatifard A, Merkle RK, Helland DE, et al. (1993). „Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.”. J. Virol. 67 (2): 943—52. PMC 237448 . PMID 8419650. doi:10.1128/JVI.67.2.943-952.1993. 
• Uchimura K, Fasakhany F, Kadomatsu K, et al. (2000). „Diversity of N-acetylglucosamine-6-O-sulfotransferases: molecular cloning of a novel enzyme with different distribution and specificities.”. Biochem. Biophys. Res. Commun. 274 (2): 291—6. PMID 10913333. doi:10.1006/bbrc.2000.3141. 
• Spiro MJ, Spiro RG (2001). „Sulfation of the N-linked oligosaccharides of influenza virus hemagglutinin: temporal relationships and localization of sulfotransferases.”. Glycobiology. 10 (11): 1235—42. PMID 11087716. doi:10.1093/glycob/10.11.1235 . 
• Liu NP, Dew-Knight S, Rayner M, et al. (2001). „Mutations in corneal carbohydrate sulfotransferase 6 gene (CHST6) cause macular corneal dystrophy in Iceland.”. Mol. Vis. 6: 261—4. PMID 11139648. 
• Hemmerich S, Lee JK, Bhakta S, et al. (2001). „Chromosomal localization and genomic organization for the galactose/ N-acetylgalactosamine/N-acetylglucosamine 6-O-sulfotransferase gene family.”. Glycobiology. 11 (1): 75—87. PMID 11181564. doi:10.1093/glycob/11.1.75 . 
• Akama TO, Nakayama J, Nishida K, et al. (2001). „Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.”. J. Biol. Chem. 276 (19): 16271—8. PMID 11278593. doi:10.1074/jbc.M009995200 . 
• Bartes A, Bhakta S, Hemmerich S (2001). „Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).”. Biochem. Biophys. Res. Commun. 282 (4): 928—33. PMID 11352640. doi:10.1006/bbrc.2001.4668. 
• El-Ashry MF, Abd El-Aziz MM, Wilkins S, et al. (2002). „Identification of novel mutations in the carbohydrate sulfotransferase gene (CHST6) causing macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 43 (2): 377—82. PMID 11818380. 
• Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). „Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.”. J. Biol. Chem. 277 (45): 42505—13. PMID 12218059. doi:10.1074/jbc.M207412200 . 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 . 
• Niel F, Ellies P, Dighiero P, et al. (2003). „Truncating mutations in the carbohydrate sulfotransferase 6 gene (CHST6) result in macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 44 (7): 2949—53. PMID 12824236. doi:10.1167/iovs.02-0740. 
• Iida-Hasegawa N, Furuhata A, Hayatsu H, et al. (2003). „Mutations in the CHST6 gene in patients with macular corneal dystrophy: immunohistochemical evidence of heterogeneity.”. Invest. Ophthalmol. Vis. Sci. 44 (8): 3272—7. PMID 12882769. doi:10.1167/iovs.02-0910. 
• Ha NT, Chau HM, Cung le X, et al. (2003). „Mutation analysis of the carbohydrate sulfotransferase gene in Vietnamese with macular corneal dystrophy.”. Invest. Ophthalmol. Vis. Sci. 44 (8): 3310—6. PMID 12882775. doi:10.1167/iovs.03-0031. 
• Ha NT, Chau HM, Cung le X, et al. (2003). „Identification of novel mutations of the CHST6 gene in Vietnamese families affected with macular corneal dystrophy in two generations.”. Cornea. 22 (6): 508—11. PMID 12883341. S2CID 25039164. doi:10.1097/00003226-200308000-00004. 
• Warren JF, Aldave AJ, Srinivasan M, et al. (2003). „Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India.”. Arch. Ophthalmol. 121 (11): 1608—12. PMID 14609920. doi:10.1001/archopht.121.11.1608. 
• Sultana A, Sridhar MS, Jagannathan A, et al. (2004). „Novel mutations of the carbohydrate sulfotransferase-6 (CHST6) gene causing macular corneal dystrophy in India.”. Mol. Vis. 9: 730—4. PMID 14735064. 
• Abbruzzese C, Kuhn U, Molina F, et al. (2004). „Novel mutations in the CHST6 gene causing macular corneal dystrophy.”. Clin. Genet. 65 (2): 120—5. PMID 14984470. S2CID 32667901. doi:10.1111/j.0009-9163.2004.00191.x.