CMP-N-acetilneuraminat monooksigenaza
| CMP-N-acetilneuraminat monooksigenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.14.18.2 | ||||||||
| CAS broj | 116036-67-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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CMP-N-acetilneuraminat monooksigenaza (EC 1.14.18.2, CMP-N-acetilneuraminska kiselina hidroksilaza, CMP-Neu5Ac hidroksilaza, citidin monofosfoacetilneuraminatna monooksigenaza, N-acetilneuraminska monooksigenaza, citidin-5'-monofosfat-N-acetilneuraminska kiselina hidroksilaza) je enzim sa sistematskim imenom CMP-N-acetilneuraminat,ferocitohrom-b5:kiseonik oksidoreduktaza (N-acetil-hidroksilacija).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetilneuraminat + 2 ferocitohrom b5 + O2 + 2 H+ CMP-N-glikoloilneuraminat + 2 fericitohrom b5 + H2O
Ovaj enzim sadrži Riskijev tip [2Fe-2S] klastera i jedan dodatno mesto vezivanja gvožđa.
Reference
[уреди | уреди извор]- ^ Shaw, L. & Schauer, R. (1988). „The biosynthesis of N-glycoloylneuraminic acid occurs by hydroxylation of the CMP-glycoside of N-acetylneuraminic acid”. Biol. Chem. Hoppe-Seyler. 369: 477—486. PMID 3202954.
- ^ Kozutsumi, Y., Kawano, T., Yamakawa, T. and Suzuki, A. (1990). „Participation of cytochrome b5 in CMP-N-acetylneuraminic acid hydroxylation in mouse liver cytosol”. J. Biochem. (Tokyo). 109: 704—706. PMID 1964451.
- ^ Schneckenburger, P., Shaw, L. and Schauer, R. (1994). „Purification, characterization and reconstitution of CMP-N-acetylneuraminate hydroxylase from mouse liver”. Glycoconj. J. 11: 194—203. PMID 7841794.
- ^ Kawano, T., Koyama, S., Takematsu, H., Kozutsumi, Y., Kawasaki, H., Kawashima, S., Kawasaki, T. and Suzuki, A. (1995). „Molecular cloning of cytidine monophospho-N-acetylneuraminic acid hydroxylase. Regulation of species- and tissue-specific expression of N-glycolylneuraminic acid”. J. Biol. Chem. 270: 16458—16463. PMID 7608218.
- ^ Schlenzka, W., Shaw, L., Kelm, S., Schmidt, C.L., Bill, E., Trautwein, A.X., Lottspeich, F. and Schauer, R. (1996). „CMP-N-acetylneuraminic acid hydroxylase: the first cytosolic Rieske iron-sulphur protein to be described in Eukarya”. FEBS Lett. 385: 197—200. PMID 8647250.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- CMP-N-acetylneuraminate+monooxygenase на US National Library of Medicine Medical Subject Headings (MeSH)
