Diacilglicerol difosfatna fosfataza
| Diacilglicerol difosfatna fosfataza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.1.3.81 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Diacilglicerol difosfatna fosfataza (EC 3.1.3.81, DGPP fosfataza, DGPP fosfohidrolaza, DPP1, DPPL1, DPPL2, PAP2, pirofosfatna fosfataza) je enzim sa sistematskim imenom 1,2-diacil-sn-glicerol 3-fosfat fosfohidrolaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 1,2-diacil-sn-glicerol 3-difosfat + H2O 1,2-diacil-sn-glicerol 3-fosfat + fosfat
Ovaj bifunkcionalni enzim katalizuje defosforilaciju diacilglicerol difosfata do fosfatidata i naknadnu defosforilaciju fosfatidata do diacilglicerola.
Reference
[уреди | уреди извор]- ^ Dillon, D.A., Wu, W.I., Riedel, B., Wissing, J.B., Dowhan, W. and Carman, G.M. (1996). „The Escherichia coli pgpB gene encodes for a diacylglycerol pyrophosphate phosphatase activity”. J. Biol. Chem. 271: 30548—30553. PMID 8940025.
- ^ Dillon, D.A., Chen, X., Zeimetz, G.M., Wu, W.I., Waggoner, D.W., Dewald, J., Brindley, D.N. and Carman, G.M. (1997). „Mammalian Mg2+-independent phosphatidate phosphatase (PAP2) displays diacylglycerol pyrophosphate phosphatase activity”. J. Biol. Chem. 272: 10361—10366. PMID 9099673.
- ^ Wu, W.I., Liu, Y., Riedel, B., Wissing, J.B., Fischl, A.S. and Carman, G.M. (1996). „Purification and characterization of diacylglycerol pyrophosphate phosphatase from Saccharomyces cerevisiae”. J. Biol. Chem. 271: 1868—1876. PMID 8567632.
- ^ Oshiro, J., Han, G.S. and Carman, G.M. (2003). „Diacylglycerol pyrophosphate phosphatase in Saccharomyces cerevisiae”. Biochim. Biophys. Acta. 1635: 1—9. PMID 14642771.
- ^ Carman, G.M. (1997). „Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli”. Biochim. Biophys. Acta. 1348: 45—55. PMID 9370315.
- ^ Han, G.S., Johnston, C.N., Chen, X., Athenstaedt, K., Daum, G. and Carman, G.M. (2001). „Regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate phosphatase by zinc”. J. Biol. Chem. 276: 10126—10133. PMID 11139591.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Diacylglycerol+diphosphate+phosphatase на US National Library of Medicine Medical Subject Headings (MeSH)
