GTPaza proteinske sinteze
| GTPaza proteinske sinteze | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.6.5.3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
GTPaza proteinske sinteze (EC 3.6.5.3, elongacioni faktor (EF), inicijacioni faktor (IF), faktor peptidnog oslobađanja ili terminacije) je enzim sa sistematskim imenom GTP fosfohidrolaza (pomoć pri iRNK translaciji).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- GTP + H2O GDP + fosfat
Ova grupa enzima pripada familiji proteina koji učestvuju u prokariotskoj, kao i u eukariotskoj, proteinskoj sintezi.
Reference
[уреди | уреди извор]- ^ Kurzchalia, T.V., Bommer, U.A., Babkina, G.T. and Karpova, G.G. (1984). „GTP interacts with the γ-subunit of eukaryotic initiation factor EIF-2”. FEBS Lett. 175: 313—316. PMID 6566615.
- ^ Kisselev, L.L. & Frolova, L.Yu. (1995). „Termination of translation in eukaryotes”. Biochem. Cell Biol. 73: 1079—1086. PMID 8722024.
- ^ Rodnina, M.V., Savelsberg, A., Katunin, V.I. and Wintermeyer, W. (1997). „Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome”. Nature. 385: 37—41. PMID 8985244.
- ^ Freistroffer, D.V., Pavlov, M.Y., MacDougall, J., Buckingham, R.H. and Ehrenberg, M. (1997). „Release factor RF3 in E. coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner”. EMBO J. 16: 4126—4133. PMID 9233821.
- ^ Krab, I.M. & Parmeggiani, A. (1998). „EF-Tu, a GTPase odyssey”. Biochim. Biophys. Acta. 1443: 1—22. PMID 9838020.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Protein-synthesizing+GTPase на US National Library of Medicine Medical Subject Headings (MeSH)
