Glutamat dehidrogenaza (NADP+)

Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glutamat dehidrogenaza (NADP⁺)
Glutamat dehidrogenaza (NADP+)
Identifikatori
EC broj	1.4.1.4
CAS broj	2604121
Baze podataka
IntEnz	IntEnz pregled
BRENDA	BRENDA pristup
ExPASy	NiceZyme pregled
KEGG	KEGG pristup
MetaCyc	metabolički put
PRIAM	profil
Strukture PBP	RCSB PDB PDBe PDBj PDBsum
PMC
Pretraga
PMC	članci
PubMed	članci
NCBI	proteini

Glutamat dehidrogenaza (NADP⁺) (EC 1.4.1.4, glutamatna dehidrogenaza, dehidrogenaza, glutamat (nikotinamid adenin dinukleotid (fosfat)), glutamatno kiselinska dehidrogenaza, L-glutamatna dehidrogenaza, L-glutaminsko kiselinska dehidrogenaza, NAD(P)⁺-glutamatna dehidrogenaza, NAD(P)H-zavisna glutamatna dehidrogenaza, glutamatna dehidrogenaza (NADP⁺)) je enzim sa sistematskim imenom L-glutamat:NADP⁺ oksidoreduktaza (deaminacija).^[1]^[2]^[3]^[4] Ovaj enzim katalizuje sledeću hemijsku reakciju

L-glutamat +H₂O + NADP⁺

\rightleftharpoons

2-oksoglutarat + NH₃ + NADPH + H⁺

Reference

^ Coulton, J.W. & Kapoor, M. (1973). „Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium”. Can. J. Microbiol. 19: 427—438. PMID 4144743.
^ Grisolia, S., Quijada, C.L. and Fernandez, M. (1964). „Glutamate dehydrogenase from yeast and from animal tissues”. Biochim. Biophys. Acta. 81: 61—70.
^ Shiio, I. & Ozaki, H. (1970). „Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium”. J. Biochem. (Tokyo). 68: 633—647. PMID 4394939.
^ Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F. (1975). „Glutamate dehydrogenases”. Ур.: Boyer, P.D. The Enzymes. 11 (3rd изд.). New York: Academic Press. стр. 293—367.

Literatura

Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.

Spoljašnje veze

Glutamate+dehydrogenase+(NADP+) на US National Library of Medicine Medical Subject Headings (MeSH)

[1] Coulton, J.W. & Kapoor, M. (1973). „Purification and some properties of the glutamate dehydrogenase of Salmonella typhimurium”. Can. J. Microbiol. 19: 427—438. PMID 4144743.

[2] Grisolia, S., Quijada, C.L. and Fernandez, M. (1964). „Glutamate dehydrogenase from yeast and from animal tissues”. Biochim. Biophys. Acta. 81: 61—70.

[3] Shiio, I. & Ozaki, H. (1970). „Regulation of nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase from Brevibacterium flavum, a glutamate-producing bacterium”. J. Biochem. (Tokyo). 68: 633—647. PMID 4394939.

[4] Smith, E.L., Austen, B.M., Blumenthal, K.M. and Nyc, J.F. (1975). „Glutamate dehydrogenases”. Ур.: Boyer, P.D. The Enzymes. 11 (3rd изд.). New York: Academic Press. стр. 293—367.

[1]

[2]

[3]

[4]

п р у CH-NH₂ oksidoreduktaze (EC 1.4) - prvenstveno aminokiselinske oksidoreduktaze
1.4.1: NAD/NADP acceptor	Glutamatna dehidrogenaza GLUD1 GLUD2 Glutamat sintaza (NADPH)
1.4.3: kiseonični akceptor	D-aminokiselina oksidaza Aminska oksidaza (koja sadrži bakar (Lizil Diamin Primarni-amin)) (sa flavinom (Monoamin)))
1.4.4: disulfidni akceptor	Sistem glicinskog razlaganja
1.4.99: drugi akceptori	D-aminokiselina dehidrogenaza Amin dehidrogenaza

п р у Enzimi
Teme	Aktivno mesto Alosterna regulacija Mesto vezivanja Katalitički perfektan enzim Koenzim Kofaktor Kooperativnost EC broj Enzimska kataliza Inhibicija enzima Enzimska kinetika Lajnviver—Berkov dijagram Mihaelis—Mentenina kinetika Spisak enzima
Tipovi	EC1 Oksidoreduktaze /spisak EC2 Transferaze /spisak EC3 Hidrolaze /spisak EC4 Lijaze /spisak EC5 Izomeraze /spisak EC6 Ligaze /spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6