Glutamatna karboksipeptidaza II
| Glutamatna karboksipeptidaza II | |||||||||
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| Identifikatori | |||||||||
| EC broj | 3.4.17.21 | ||||||||
| CAS broj | 9074-87-7 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Glutamatna karboksipeptidaza II (EC 3.4.17.21, N-acetilisana-gama-vezana-kiselinska dipeptidaza (NAALADaza), folatna hidrolaza, prostat-specifični membranski antigen, pteroilpoli-gama-glutamatna karboksipeptidaza, mikrozomalna gama-glutamilna karboksipeptidaza, pteroilpoliglutamatna hidrolaza, folilpoliglutamatna hidrolaza, pteroilpoli-gama-glutamatna hidrolaza, pteroilpoligamaglutamilna hidrolaza, pteroilpoliglutamatna hidrolaza, pteroilpoliglutaminsko kiselinska hidrolaza, PSM antigen, acetilaspartilglutamatna dipeptidaza, NAALA dipeptidaza, NAAG peptidaza pacova, mGCP, membranska glutamatna karboksipeptidaza, N-acetilisana-alfa-vezana-amino dipeptidaza, prostratno-specifični membranski antigen, N-acetilisana alfa-vezana kiselinska dipeptidaza, PSMA) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Odvajanje nesupstituisanog, C-terminalnog glutaminskog ostatka, tipično sa Ac-Asp-Glu ili folilpoli-gama-glutamata
Ova metalo-karboksipeptidaza je predominantno izražena kao membranski enzim koji je težak 94-100 kDa.
Reference
[уреди | уреди извор]- ^ Heston, W.D.W. (1997). „Characterization and glutamyl preferring carboxypeptidase function of prostate specific membrane antigen: a novel folate hydrolase”. Urology. 49: 104—112. PMID 9123729.
- ^ Rawlings, N.D. & Barrett, A.J. (1997). „Structure of membrane glutamate carboxypeptidase”. Biochim. Biophys. Acta. 1339: 247—252. PMID 9187245.
- ^ Halsted, C.H., Ling, E.-H., Luthi-Carter, R., Villanueva, J.A., Gardner, J.M., Coyle, J.T. (1998). „Folylpoly-γ-glutamate carboxypeptidase from pig jejunum: molecular characterization and relation to glutamate carboxypeptidase II”. J. Biol. Chem. 273: 20417—20424. PMID 9685395.
- ^ Luthi-Carter, R., Berger, U.V., Barczak, A.K., Enna, M. and Coyle, J.T. (1998). „Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II”. Proc. Natl. Acad. Sci. USA. 95: 3215—3220. PMID 9501243.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Glutamate+carboxypeptidase+II на US National Library of Medicine Medical Subject Headings (MeSH)
