Glutaril-KoA dehidrogenaza
| Glutaril-KoA dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Glutaril-KoA dehidrogenaza tetramer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 1.3.8.6 | ||||||||
| CAS broj | 37255-38-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Glutaril-KoA dehidrogenaza (EC 1.3.8.6, glutarilna koenzim A dehidrogenaza, glutaril-KoA:(akceptor) 2,3-oksidoreduktaza (dekarboksilacija)) je enzim sa sistematskim imenom glutaril-KoA:elektron-transfer flavoprotein 2,3-oksidoreduktaza (dekarboksilacija).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- glutaril-KoA + elektron-transfer flavoprotein (E)-but-2-enoil-KoA + CO2 + redukovani elektron-transfer flavoprotein (sveukupna reakcija)
- (1a) glutaril-KoA + elektron-transfer flavoprotein (2E)-4-karboksibut-2-enoil-KoA + redukovani elektron-transfer flavoprotein
- (1b) (2E)-4-karboksibut-2-enoil-KoA (E)-but-2-enoil-KoA + CO2
Ovaj enzim sadrži FAD. Enzim katalizuje oksidaciju glutaril-KoA do glutakonil-KoA.
Reference
[уреди | уреди извор]- ^ Besrat, A., Polan, C.E. and Henderson, L.M. (1969). „Mammalian metabolism of glutaric acid”. J. Biol. Chem. 244: 1461—1467. PMID 4304226.
- ^ Hartel, U., Eckel, E., Koch, J., Fuchs, G., Linder, D. and Buckel, W. (1993). „Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate”. Arch. Microbiol. 159: 174—181. PMID 8439237.
- ^ Dwyer, T.M., Zhang, L., Muller, M., Marrugo, F. and Frerman, F. (1999). „The functions of the flavin contact residues, αArg249 and βTyr16, in human electron transfer flavoprotein”. Biochim. Biophys. Acta. 1433: 139—152. PMID 10446367.
- ^ Rao, K.S., Albro, M., Dwyer, T.M. and Frerman, F.E. (2006). „Kinetic mechanism of glutaryl-CoA dehydrogenase”. Biochemistry. 45: 15853—15861. PMID 17176108.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Glutaryl-CoA+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
