ICRF 193

ICRF 193
Nazivi
	IUPAC naziv 4-[2-(3,5-Dioxo-1-piperazinyl)-1-methylpropyl]piperazine-2,6-dione
Identifikacija
CAS broj	21416-68-2;
3D model (Jmol)	interaktivna slika;
MeSH	ICRF+193
PubChem C ID	115150;
	SMILES CC(C(C)N1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2; ; ; ; ; ;
Svojstva
Hemijska formula	C12H18N4O4
Molarna masa	282,30 g/mol
	Ukoliko nije drugačije napomenuto, podaci se odnose na standardno stanje materijala (na 25 °C [77 °F], 100 kPa).
	Reference infokutije

ICRF 193 je inhibitor topoizomeraze.^[3] Precizna segregacija hromozoma kokom mitoze je neophodna za održavanje genomske stabilnosti i za izbegavanje aneuploidije u novonastalim ćelijama. Važan proces neposredno pre ulaska u mitozu je razdvajanje hromozoma koji se u znatnoj meri isprepleću tokom replikacije DNK.^[4] Individualizacija hromozoma se postiže katalitičkom akcijom evoluciono konzerviranih enzima topoizomeraza. Iz tog razloga inhibitori topoizomeraze su značajna klasa lekova.

Reference

^ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди
^ Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.
^ Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA (2007). „Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193”. Cell Cycle. 6 (10): 1265—7. PMID 17495539.
^ Donald Voet; Judith G. Voet (2005). „Chapter 30. DNA Replication, Repair, and Recombination”. Biochemistry (3 изд.). Wiley. ISBN 9780471193500.

Literatura

Spoljašnje veze

[1] Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today. 15 (23-24): 1052—7. PMID 20970519. doi:10.1016/j.drudis.2010.10.003. уреди

[2] Evan E. Bolton; Yanli Wang; Paul A. Thiessen; Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry. 4: 217—241. doi:10.1016/S1574-1400(08)00012-1.

[pmid17495539-3] Robinson HM, Bratlie-Thoresen S, Brown R, Gillespie DA (2007). „Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193”. Cell Cycle. 6 (10): 1265—7. PMID 17495539.

[VoetBiochemistry3rd-4] Donald Voet; Judith G. Voet (2005). „Chapter 30. DNA Replication, Repair, and Recombination”. Biochemistry (3 изд.). Wiley. ISBN 9780471193500.

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