Kaspaza-5
(преусмерено са Kaspaza 5)
| Kaspaza-5 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.58 | ||||||||
| CAS broj | 192465-11-5 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Kaspaza-5 (EC 3.4.22.58, ICErel-III, Ich-3, ICH-3 proteaza, transkript Y, TY, CASP-5) je enzim.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Neophodno je prisustvo Asp ostatka u P1 poziciji. Preferentno dolazi do razlaganja sekvence Tyr-Val-Ala-Asp- ali se takođe razlaže Asp-Glu-Val-Asp-
Ovaj enzim pripada familiji inflamatornih kaspaza, koja takođe obuhvata kaspazu-1 (EC 3.4.22.36) i kaspazu-4 (EC 3.4.22.57) kod ljudi i kaspazu-11 (EC 3.4.22.64), kaspazu-12, kaspazu-13 i kaspazu-14 kod miševa.
Reference
[уреди | уреди извор]- ^ Faucheu, C., Blanchet, A.M., Collard-Dutilleul, V., Lalanne, J.L. and Diu-Hercend, A. (1996). „Identification of a cysteine protease closely related to interleukin-1 β-converting enzyme”. Eur. J. Biochem. 236: 207—213. PMID 8617266.
- ^ Kamada, S., Funahashi, Y. and Tsujimoto, Y. (1997). „Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases”. Cell Death Differ. 4: 473—478. PMID 16465268.
- ^ Lin, X.Y., Choi, M.S. and Porter, A.G. (2000). „Expression analysis of the human caspase-1 subfamily reveals specific regulation of the CASP5 gene by lipopolysaccharide and interferon-γ”. J. Biol. Chem. 275: 39920—39926. PMID 10986288.
- ^ Fassy, F., Krebs, O., Rey, H., Komara, B., Gillard, C., Capdevila, C., Yea, C., Faucheu, C., Blanchet, A.M., Miossec, C. and Diu-Hercend, A. (1998). „Enzymatic activity of two caspases related to interleukin-1β-converting enzyme”. Eur. J. Biochem. 253: 76—83. PMID 9578463.
- ^ Martinon, F. & Tschopp, J. (2004). „Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases”. Cell. 117: 561—574. PMID 15163405.
- ^ Chang, H.Y. & Yang, X. (2000). „Proteases for cell suicide: functions and regulation of caspases”. Microbiol. Mol. Biol. Rev. 64: 821—846. PMID 11104820.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
