Komplementna potkomponenta C1s
| Komplementna potkomponenta C1s | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.42 | ||||||||
| CAS broj | 80295-70-1 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Komplementna potkomponenta C1s (EC 3.4.21.42, C1 esteraza, aktivirani komplement C1s, komplement C overbar 1r) je enzim.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Razlaganje Arg-Ala veze u komplementnoj komponenti C4 čime se formiraju C4a i C4b, i Lys(ili Arg)-Lys veze u komplementnoj komponenti C2 čime se formiraju C2a i C2b: "klasični" put C3 konvertaze
Ovaj enzim se aktivira iz proenzima C1s u plasmi dejstvom komplementne potkomponente C overbar 1r.
Reference
[уреди | уреди извор]- ^ Sim, R.B. (1981). „T'he human complement system serine proteases C1r and C1s and their proenzymes”. Methods Enzymol. 80: 26—42. PMID 6281620.
- ^ MacKinnon, C.M., Carter, P.E., Smyth, S.J., Dunbar, B. and Fothergill, J.E. (1987). „Molecular cloning of cDNA for human complement component C1s. The complete amino acid sequence”. Eur. J. Biochem. 169: 547—553. PMID 3500856.
- ^ Müller-Eberhard, H.J. (1988). „Molecular organization and function of the complement system”. Annu. Rev. Biochem. 57: 321—347. PMID 3052276.
- ^ Skoog, M.T., Mehdi, S., Wiseman, J.S. and Bey, P. The specificity of two proteinases that cleave adjacent to arginine, C (1989). „1 esterase and acrosin, for peptide p-nitroanilide substrates”. Biochim. Biophys. Acta. 996: 89—94. PMID 2500154.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Complement+subcomponent+C_overbar_1s_ на US National Library of Medicine Medical Subject Headings (MeSH)
