Nelarabin

Nelarabin
Klinički podaci
Prodajno ime	Arranon, Arranon (GlaxoSmithKline), Atriance
Drugs.com	Monografija
Način primene	Intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	30 minuta - 3 h
Izlučivanje	Renalno
Identifikatori
CAS broj	121032-29-9
ATC kod	L01BB07 (WHO)
PubChem	CID 3011155
DrugBank	DB01280
ChemSpider	2280207
ChEMBL	CHEMBL1201112
Hemijski podaci
Formula	C11H15N5O5
Molarna masa	297,267
	SMILES COC1=NC(N)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O; ;
	InChI InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1 ; Key:IXOXBSCIXZEQEQ-UHTZMRCNSA-N ;
Fizički podaci
Tačka topljenja	209—217 °C (408—423 °F)

Nelarabin je organsko jedinjenje, koje sadrži 11 atoma ugljenika i ima molekulsku masu od 297,267 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	9
Broj donora vodonika	4
Broj rotacionih veza	3
Particioni koeficijent^[8] (ALogP)	-1,4
Rastvorljivost^[9] (logS, log(mol/L))	-0,4
Polarna površina^[10] (PSA, Å²)	148,8

Reference

^ Buie, L. W.; Epstein, S. S.; Lindley, C. M. (септембар 2007). „Nelarabine: A novel purine antimetabolite antineoplastic agent”. Clin Ther. 29 (9): 1887—99. PMID 18035189. doi:10.1016/j.clinthera.2007.09.002.
^ Deangelo, D. J. (октобар 2009). „Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma”. Hematol Oncol Clin North Am. 23 (5): 1121—35. PMID 19825456. doi:10.1016/j.hoc.2009.07.008.
^ Roecker, A. M.; Allison, J. C.; Kisor, D. F. (август 2006). „Nelarabine: Efficacy in the treatment of clinical malignancies”. Future Oncol. 2 (4): 441—8. PMID 16922610. doi:10.2217/14796694.2.4.441.
^ Sanford, M.; Lyseng-Williamson, K. A. (2008). „Nelarabine”. Drugs. 68 (4): 439—47. PMID 18318562. doi:10.2165/00003495-200868040-00004.
^ Reilly, K. M.; Kisor, D. F. (фебруар 2009). „Profile of nelarabine: Use in the treatment of T-cell acute lymphoblastic leukemia”. Onco Targets Ther. 18 (2): 219—28. PMC 2886323 . PMID 20616909. doi:10.2147/ott.s4770 .
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Nelarabine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Buie, L. W.; Epstein, S. S.; Lindley, C. M. (септембар 2007). „Nelarabine: A novel purine antimetabolite antineoplastic agent”. Clin Ther. 29 (9): 1887—99. PMID 18035189. doi:10.1016/j.clinthera.2007.09.002.

[2] Deangelo, D. J. (октобар 2009). „Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma”. Hematol Oncol Clin North Am. 23 (5): 1121—35. PMID 19825456. doi:10.1016/j.hoc.2009.07.008.

[3] Roecker, A. M.; Allison, J. C.; Kisor, D. F. (август 2006). „Nelarabine: Efficacy in the treatment of clinical malignancies”. Future Oncol. 2 (4): 441—8. PMID 16922610. doi:10.2217/14796694.2.4.441.

[4] Sanford, M.; Lyseng-Williamson, K. A. (2008). „Nelarabine”. Drugs. 68 (4): 439—47. PMID 18318562. doi:10.2165/00003495-200868040-00004.

[5] Reilly, K. M.; Kisor, D. F. (фебруар 2009). „Profile of nelarabine: Use in the treatment of T-cell acute lymphoblastic leukemia”. Onco Targets Ther. 18 (2): 219—28. PMC 2886323 . PMID 20616909. doi:10.2147/ott.s4770 .

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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