O-sukcinilbenzoatna sintaza
| O-sukcinilbenzoatna sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.2.1.113 | ||||||||
| CAS broj | 97089-83-3 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
O-sukcinilbenzoatna sintaza (EC 4.2.1.113, o-sukcinilbenzojevo kiselinska sintaza, OSB sintaza, OSBS, 2-sukcinilbenzoatna sintaza, MenC) je enzim sa sistematskim imenom (1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat hidrolijaza (formira 2-sukcinilbenzoat).[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1R,6R)-6-hidroksi-2-sukcinilcikloheksa-2,4-dien-1-karboksilat 2-sukcinilbenzoat + H2O
Ovaj enzim pripada enolaznoj superfamiliji.
Reference
[уреди | уреди извор]- ^ Sharma, V., Meganathan, R. and Hudspeth, M.E. (1993). „Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli”. J. Bacteriol. 175: 4917—4921. PMID 8335646.
- ^ Klenchin, V.A., Taylor Ringia, E.A., Gerlt, J.A. and Rayment, I. (2003). „Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli”. Biochemistry. 42: 14427—14433. PMID 14661953.
- ^ Palmer, D.R., Garrett, J.B., Sharma, V., Meganathan, R., Babbitt, P.C. and Gerlt, J.A. (1999). „Unexpected divergence of enzyme function and sequence: "N-acylamino acid racemase" is o-succinylbenzoate synthase”. Biochemistry. 38: 4252—4258. PMID 10194342.
- ^ Thompson, T.B., Garrett, J.B., Taylor, E.A., Meganathan, R., Gerlt, J.A. and Rayment, I. (2000). „Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate”. Biochemistry. 39: 10662—10676. PMID 10978150.
- ^ Taylor Ringia, E.A., Garrett, J.B., Thoden, J.B., Holden, H.M., Rayment, I. and Gerlt, J.A. (2004). „Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis”. Biochemistry. 43: 224—229. PMID 14705949.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- O-succinylbenzoate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
