Пређи на садржај

Proliferatini ćelijski nuklearni antigen

С Википедије, слободне енциклопедије
Proliferating cell nuclear antigen
Identifikatori
Alijasi
Spoljašnji IDGeneCards: [1]
Obrazac RNK izražavanja
More reference expression data
Ortolozi
VrsteČovekMiš
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proliferativni ćelijski nuklearni antigen (PCNA) je DNK stega koja deluje kao faktor procesivnosti za DNK polimerazu δ u eukariotskim ćelijama i koja je esencijalna za replikaciju. PCNA je homotrimer koji ostvaruje svoju procesivnost putem obuhvatanja DNK, pri čemu ona deluje kao osnova na kojoj se vezuju drugi proteini koji su neophodni za DNK replikaciju, DNK popravku, remodelovanje hromatina i epigenetiku.[1]

Mnogi proteini formiraju interakcije sa dva poznata PCNA-interagujuća motiva: PCNA interagujuća peptidna (PIP) kutija[2] i AlkB homolog 2 PCNA interagujući motiv (APIM).[3] Proteinsko vezivanje za PCNA putem PIP-kutije se uglavnom ostvaruje tokom DNK replikacije, dok su proteini koji se vezuju za PCNA putem APIM prvenstveno važni u kontekstu genotoksičnog stresa.[4]

U responsu na DNK oštećenje, ovaj protein biva ubikvitinisan i učestvuje u putu RAD6 zavisne DNK popravke. Poznate su dve transkriptne varijante koje kodiraju isti protein. Pseudogeni ovog gena su prisutni na hromozomu 4 i na X hromozomu.[5]

Interakcije

[уреди | уреди извор]

PCNA formira interakcije sa:

Proteini koji formiraju interakcije sa PCNA preko APIM obuhvataju ljudski AlkB homolog 2, TFIIS-L, TFII-I, Rad51B,[3] XPA,[69] ZRANB3,[70] i FBH1.[71]

Reference

[уреди | уреди извор]
  1. ^ Moldovan, GL; Pfander, B; Jentsch, S (18. 5. 2007). „PCNA, the maestro of the replication fork.”. Cell. 129 (4): 665—79. PMID 17512402. doi:10.1016/j.cell.2007.05.003. 
  2. ^ Warbrick, E (1998). „PCNA binding through a conserved motif.”. BioEssays : news and reviews in molecular, cellular and developmental biology. 20 (3): 195—9. PMID 9631646. doi:10.1002/(sici)1521-1878(199803)20:3<195::aid-bies2>3.0.co;2-r. 
  3. ^ а б Gilljam, KM; Feyzi, E; Aas, PA; Sousa, MM; Müller, R; Vågbø, CB; Catterall, TC; Liabakk, NB; Slupphaug, G; Drabløs, F; Krokan, HE; Otterlei, M (7. 9. 2009). „Identification of a novel, widespread, and functionally important PCNA-binding motif.”. The Journal of cell biology. 186 (5): 645—54. PMID 19736315. doi:10.1083/jcb.200903138. 
  4. ^ Mailand, N; Gibbs-Seymour, I; Bekker-Jensen, S (2013). „Regulation of PCNA-protein interactions for genome stability.”. Nature reviews. Molecular cell biology. 14 (5): 269—82. PMID 23594953. doi:10.1038/nrm3562. 
  5. ^ „Entrez Gene: PCNA proliferating cell nuclear antigen”. 
  6. ^ а б в г д ђ е ж з и ј к л Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (2002). „A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein”. J. Biol. Chem. 277 (43): 40362—7. PMID 12171929. doi:10.1074/jbc.M206194200. 
  7. ^ Zhang K, Gao Y, Li J, Burgess R, Han J, Liang H, Zhang Z, Liu Y (2016). „A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks”. Nucleic Acids Research. 44 (11): 5083—94. PMC 4914081 Слободан приступ. PMID 26908650. doi:10.1093/nar/gkw106. 
  8. ^ Moggs JG, Grandi P, Quivy JP, Jónsson ZO, Hübscher U, Becker PB, Almouzni G (2000). „A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage”. Molecular and Cellular Biology. 20 (4): 1206—18. PMC 85246 Слободан приступ. PMID 10648606. 
  9. ^ Rolef Ben-Shahar T, Castillo AG, Osborne MJ, Borden KL, Kornblatt J, Verreault A (2009). „Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function”. Molecular and Cellular Biology. 29 (24): 6353—65. PMC 2786881 Слободан приступ. PMID 19822659. doi:10.1128/MCB.01051-09. 
  10. ^ Kawabe T, Suganuma M, Ando T, Kimura M, Hori H, Okamoto T (2002). „Cdc25C interacts with PCNA at G2/M transition”. Oncogene. 21 (11): 1717—26. PMID 11896603. doi:10.1038/sj.onc.1205229. 
  11. ^ Matsuoka S, Yamaguchi M, Matsukage A (1994). „D-type cyclin-binding regions of proliferating cell nuclear antigen”. J. Biol. Chem. 269 (15): 11030—6. PMID 7908906. 
  12. ^ а б Xiong Y, Zhang H, Beach D (1993). „Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation”. Genes Dev. 7 (8): 1572—83. PMID 8101826. doi:10.1101/gad.7.8.1572. 
  13. ^ Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE (1999). „Post-replicative base excision repair in replication foci”. EMBO J. 18 (13): 3834—44. PMC 1171460 Слободан приступ. PMID 10393198. doi:10.1093/emboj/18.13.3834. 
  14. ^ Serrano M, Hannon GJ, Beach D (1993). „A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4”. Nature. 366 (6456): 704—7. PMID 8259215. doi:10.1038/366704a0. 
  15. ^ а б Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y (1998). „Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1392—7. PMC 19016 Слободан приступ. PMID 9465025. doi:10.1073/pnas.95.4.1392. 
  16. ^ Rountree MR, Bachman KE, Baylin SB (2000). „DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci”. Nat. Genet. 25 (3): 269—77. PMID 10888872. doi:10.1038/77023. 
  17. ^ Iida T, Suetake I, Tajima S, Morioka H, Ohta S, Obuse C, Tsurimoto T (2002). „PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA”. Genes Cells. 7 (10): 997—1007. PMID 12354094. doi:10.1046/j.1365-2443.2002.00584.x. 
  18. ^ Chuang LS, Ian HI, Koh TW, Ng HH, Xu G, Li BF (1997). „Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1”. Science. 277 (5334): 1996—2000. PMID 9302295. doi:10.1126/science.277.5334.1996. 
  19. ^ Hasan S, Hassa PO, Imhof R, Hottiger MO (2001). „Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis”. Nature. 410 (6826): 387—91. PMID 11268218. doi:10.1038/35066610. 
  20. ^ Henneke G, Koundrioukoff S, Hübscher U (2003). „Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation”. Oncogene. 22 (28): 4301—13. PMID 12853968. doi:10.1038/sj.onc.1206606. 
  21. ^ Hasan S, Stucki M, Hassa PO, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger MO (2001). „Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300”. Mol. Cell. 7 (6): 1221—31. PMID 11430825. doi:10.1016/s1097-2765(01)00272-6. 
  22. ^ а б Jónsson ZO, Hindges R, Hübscher U (1998). „Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen”. EMBO J. 17 (8): 2412—25. PMC 1170584 Слободан приступ. PMID 9545252. doi:10.1093/emboj/17.8.2412. 
  23. ^ Gary R, Ludwig DL, Cornelius HL, MacInnes MA, Park MS (1997). „The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21”. J. Biol. Chem. 272 (39): 24522—9. PMID 9305916. doi:10.1074/jbc.272.39.24522. 
  24. ^ Chen U, Chen S, Saha P, Dutta A (1996). „p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex”. Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11597—602. PMC 38103 Слободан приступ. PMID 8876181. doi:10.1073/pnas.93.21.11597. 
  25. ^ Dianova II, Bohr VA, Dianov GL (2001). „Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair”. Biochemistry. 40 (42): 12639—44. PMID 11601988. doi:10.1021/bi011117i. 
  26. ^ а б в Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y (2001). „p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues”. Oncogene. 20 (4): 484—9. PMID 11313979. doi:10.1038/sj.onc.1204113. 
  27. ^ Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJ (1994). „Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen”. Science. 266 (5189): 1376—80. PMID 7973727. doi:10.1126/science.7973727. 
  28. ^ Chen IT, Smith ML, O'Connor PM, Fornace AJ (1995). „Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA”. Oncogene. 11 (10): 1931—7. PMID 7478510. 
  29. ^ Vairapandi M, Azam N, Balliet AG, Hoffman B, Liebermann DA (2000). „Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. PCNA impedes MyD118 AND Gadd45-mediated negative growth control”. J. Biol. Chem. 275 (22): 16810—9. PMID 10828065. doi:10.1074/jbc.275.22.16810. 
  30. ^ Hall PA, Kearsey JM, Coates PJ, Norman DG, Warbrick E, Cox LS (1995). „Characterisation of the interaction between PCNA and Gadd45”. Oncogene. 10 (12): 2427—33. PMID 7784094. 
  31. ^ Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW (2000). „Identification of a functional domain in a GADD45-mediated G2/M checkpoint”. J. Biol. Chem. 275 (47): 36892—8. PMID 10973963. doi:10.1074/jbc.M005319200. 
  32. ^ Azam N, Vairapandi M, Zhang W, Hoffman B, Liebermann DA (2001). „Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control”. J. Biol. Chem. 276 (4): 2766—74. PMID 11022036. doi:10.1074/jbc.M005626200. 
  33. ^ Nakayama K, Hara T, Hibi M, Hirano T, Miyajima A (1999). „A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth”. J. Biol. Chem. 274 (35): 24766—72. PMID 10455148. doi:10.1074/jbc.274.35.24766. 
  34. ^ Milutinovic S, Zhuang Q, Szyf M (2002). „Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification”. J. Biol. Chem. 277 (23): 20974—8. PMID 11929879. doi:10.1074/jbc.M202504200. 
  35. ^ Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG (2000). „PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition”. Oncogene. 19 (46): 5291—7. PMID 11077446. doi:10.1038/sj.onc.1203901. 
  36. ^ Scott M, Bonnefin P, Vieyra D, Boisvert FM, Young D, Bazett-Jones DP, Riabowol K (2001). „UV-induced binding of ING1 to PCNA regulates the induction of apoptosis”. J. Cell. Sci. 114 (Pt 19): 3455—62. PMID 11682605. 
  37. ^ He H, Tan CK, Downey KM, So AG (2001). „A tumor necrosis factor alpha- and interleukin 6-inducible protein that interacts with the small subunit of DNA polymerase delta and proliferating cell nuclear antigen”. Proc. Natl. Acad. Sci. U.S.A. 98 (21): 11979—84. PMC 59753 Слободан приступ. PMID 11593007. doi:10.1073/pnas.221452098. 
  38. ^ а б Balajee AS, Geard CR (2001). „Chromatin-bound PCNA complex formation triggered by DNA damage occurs independent of the ATM gene product in human cells”. Nucleic Acids Res. 29 (6): 1341—51. PMC 29758 Слободан приступ. PMID 11239001. doi:10.1093/nar/29.6.1341. 
  39. ^ Matheos D, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2002). „Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication”. Biochim. Biophys. Acta. 1578 (1–3): 59—72. PMID 12393188. doi:10.1016/s0167-4781(02)00497-9. 
  40. ^ Fujise K, Zhang D, Liu J, Yeh ET (2000). „Regulation of apoptosis and cell cycle progression by MCL1. Differential role of proliferating cell nuclear antigen”. J. Biol. Chem. 275 (50): 39458—65. PMID 10978339. doi:10.1074/jbc.M006626200. 
  41. ^ а б Kleczkowska HE, Marra G, Lettieri T, Jiricny J (2001). „hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci”. Genes Dev. 15 (6): 724—36. PMC 312660 Слободан приступ. PMID 11274057. doi:10.1101/gad.191201. 
  42. ^ а б Clark AB, Valle F, Drotschmann K, Gary RK, Kunkel TA (2000). „Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes”. J. Biol. Chem. 275 (47): 36498—501. PMID 11005803. doi:10.1074/jbc.C000513200. 
  43. ^ Parker A, Gu Y, Mahoney W, Lee SH, Singh KK, Lu AL (2001). „Human homolog of the MutY repair protein (hMYH) physically interacts with proteins involved in long patch DNA base excision repair”. J. Biol. Chem. 276 (8): 5547—55. PMID 11092888. doi:10.1074/jbc.M008463200. 
  44. ^ а б Fotedar R, Mossi R, Fitzgerald P, Rousselle T, Maga G, Brickner H, Messier H, Kasibhatla S, Hübscher U, Fotedar A (1996). „A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells”. EMBO J. 15 (16): 4423—33. PMC 452166 Слободан приступ. PMID 8861969. 
  45. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). „Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173—8. PMID 16189514. doi:10.1038/nature04209. 
  46. ^ Frouin I, Maga G, Denegri M, Riva F, Savio M, Spadari S, Prosperi E, Scovassi AI (2003). „Human proliferating cell nuclear antigen, poly(ADP-ribose) polymerase-1, and p21waf1/cip1. A dynamic exchange of partners”. J. Biol. Chem. 278 (41): 39265—8. PMID 12930846. doi:10.1074/jbc.C300098200. 
  47. ^ Gulbis JM, Kelman Z, Hurwitz J, O'Donnell M, Kuriyan J (1996). „Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA”. Cell. 87 (2): 297—306. PMID 8861913. doi:10.1016/s0092-8674(00)81347-1. 
  48. ^ Touitou R, Richardson J, Bose S, Nakanishi M, Rivett J, Allday MJ (2001). „A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome”. EMBO J. 20 (10): 2367—75. PMC 125454 Слободан приступ. PMID 11350925. doi:10.1093/emboj/20.10.2367. 
  49. ^ Lu X, Tan CK, Zhou JQ, You M, Carastro LM, Downey KM, So AG (2002). „Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta”. J. Biol. Chem. 277 (27): 24340—5. PMID 11986310. doi:10.1074/jbc.M200065200. 
  50. ^ Ducoux M, Urbach S, Baldacci G, Hübscher U, Koundrioukoff S, Christensen J, Hughes P (2001). „Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta”. J. Biol. Chem. 276 (52): 49258—66. PMID 11595739. doi:10.1074/jbc.M106990200. 
  51. ^ Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (2003). „Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen”. J. Biol. Chem. 278 (12): 10041—7. PMID 12522211. doi:10.1074/jbc.M208694200. 
  52. ^ Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S (2001). „Physical and functional interactions of human DNA polymerase eta with PCNA”. Mol. Cell. Biol. 21 (21): 7199—206. PMC 99895 Слободан приступ. PMID 11585903. doi:10.1128/MCB.21.21.7199-7206.2001. 
  53. ^ Haracska L, Unk I, Johnson RE, Phillips BB, Hurwitz J, Prakash L, Prakash S (2002). „Stimulation of DNA synthesis activity of human DNA polymerase kappa by PCNA”. Mol. Cell. Biol. 22 (3): 784—91. PMC 133560 Слободан приступ. PMID 11784855. doi:10.1128/mcb.22.3.784-791.2002. 
  54. ^ Maga G, Villani G, Ramadan K, Shevelev I, Tanguy Le Gac N, Blanco L, Blanca G, Spadari S, Hübscher U (2002). „Human DNA polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis”. J. Biol. Chem. 277 (50): 48434—40. PMID 12368291. doi:10.1074/jbc.M206889200. 
  55. ^ Shimazaki N, Yoshida K, Kobayashi T, Toji S, Tamai K, Koiwai O (2002). „Over-expression of human DNA polymerase lambda in E. coli and characterization of the recombinant enzyme”. Genes Cells. 7 (7): 639—51. PMID 12081642. doi:10.1046/j.1365-2443.2002.00547.x. 
  56. ^ Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (2002). „A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase”. Mol. Cell. Biol. 22 (18): 6509—20. PMC 135621 Слободан приступ. PMID 12192049. doi:10.1128/mcb.22.18.6509-6520.2002. 
  57. ^ а б Mossi R, Jónsson ZO, Allen BL, Hardin SH, Hübscher U (1997). „Replication factor C interacts with the C-terminal side of proliferating cell nuclear antigen”. J. Biol. Chem. 272 (3): 1769—76. PMID 8999859. doi:10.1074/jbc.272.3.1769. 
  58. ^ van der Kuip H, Carius B, Haque SJ, Williams BR, Huber C, Fischer T (1999). „The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins”. J. Mol. Med. 77 (4): 386—92. PMID 10353443. doi:10.1007/s001090050365. 
  59. ^ а б в Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (1997). „A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme”. J. Biol. Chem. 272 (30): 18974—81. PMID 9228079. doi:10.1074/jbc.272.30.18974. 
  60. ^ Pan ZQ, Chen M, Hurwitz J (1993). „The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis”. Proc. Natl. Acad. Sci. U.S.A. 90 (1): 6—10. PMC 45588 Слободан приступ. PMID 8093561. doi:10.1073/pnas.90.1.6. 
  61. ^ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (2003). „Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment”. J. Biol. Chem. 278 (32): 30051—6. PMID 12766176. doi:10.1074/jbc.M211591200. 
  62. ^ Motegi A, Liaw HJ, Lee KY, Roest HP, Maas A, Wu X, Moinova H, Markowitz SD, Ding H, Hoeijmakers JH, Myung K (2008). „Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks”. Proc. Natl. Acad. Sci. U.S.A. 105 (34): 12411—6. PMC 2518831 Слободан приступ. PMID 18719106. doi:10.1073/pnas.0805685105. 
  63. ^ Unk I, Hajdú I, Fátyol K, Hurwitz J, Yoon JH, Prakash L, Prakash S, Haracska L (2008). „Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination”. Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3768—73. PMC 2268824 Слободан приступ. PMID 18316726. doi:10.1073/pnas.0800563105. 
  64. ^ Brun J, Chiu R, Lockhart K, Xiao W, Wouters BG, Gray DA (2008). „hMMS2 serves a redundant role in human PCNA polyubiquitination”. BMC Mol. Biol. 9: 24. PMC 2263069 Слободан приступ. PMID 18284681. doi:10.1186/1471-2199-9-24. 
  65. ^ Rodríguez-López AM, Jackson DA, Nehlin JO, Iborra F, Warren AV, Cox LS (2003). „Characterisation of the interaction between WRN, the helicase/exonuclease defective in progeroid Werner's syndrome, and an essential replication factor, PCNA”. Mech. Ageing Dev. 124 (2): 167—74. PMID 12633936. doi:10.1016/s0047-6374(02)00131-8. 
  66. ^ Huang S, Beresten S, Li B, Oshima J, Ellis NA, Campisi J (2000). „Characterization of the human and mouse WRN 3'-->5' exonuclease”. Nucleic Acids Res. 28 (12): 2396—405. PMC 102739 Слободан приступ. PMID 10871373. doi:10.1093/nar/28.12.2396. 
  67. ^ Fan J, Otterlei M, Wong HK, Tomkinson AE, Wilson DM (2004). „XRCC1 co-localizes and physically interacts with PCNA”. Nucleic Acids Res. 32 (7): 2193—201. PMC 407833 Слободан приступ. PMID 15107487. doi:10.1093/nar/gkh556. 
  68. ^ Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, Izumi H, Ohmori H, Okamoto T, Ohga T, Uchiumi T, Kuwano M, Kohno K (1999). „Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen”. Cancer Res. 59 (2): 342—6. PMID 9927044. 
  69. ^ Gilljam KM, Müller R, Liabakk NB, Otterlei M (2012). „Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.”. PLoS ONE. 7 (11): e49199. PMC 3496702 Слободан приступ. PMID 23152873. doi:10.1371/journal.pone.0049199. 
  70. ^ Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ (10. 8. 2012). „Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.”. Molecular Cell. 47 (3): 396—409. PMC 3613862 Слободан приступ. PMID 22704558. doi:10.1016/j.molcel.2012.05.024. 
  71. ^ Bacquin A, Pouvelle C, Siaud N, Perderiset M, Salomé-Desnoulez S, Tellier-Lebegue C, Lopez B, Charbonnier JB, Kannouche PL (2013). „The helicase FBH1 is tightly regulated by PCNA via CRL4(Cdt2)-mediated proteolysis in human cells.”. Nucleic Acids Research. 41 (13): 6501—13. PMC 3711418 Слободан приступ. PMID 23677613. doi:10.1093/nar/gkt397. 

Literatura

[уреди | уреди извор]

Spoljašnje veze

[уреди | уреди извор]
Преузето из „https://sr.wikipedia.org/w/index.php?title=Proliferatini_ćelijski_nuklearni_antigen&oldid=27673904”