Prostaglandin-I sintaza
| Prostaglandin-I sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifikatori | |||||||||
| EC broj | 5.3.99.4 | ||||||||
| CAS broj | 65802-86-0 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Prostaglandin-I sintaza (EC 5.3.99.4, prostaciklinska sintaza, prostaciklinska sintetaza, prostagladinska I2 sintetaza, PGI2 sintaza, PGI2 sintetaza) je enzim sa sistematskim imenom (5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat 6-izomeraza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (5Z,13E)-(15S)-9alfa,11alfa-epidioksi-15-hidroksiprosta-5,13-dienoat (5Z,13E)-(15S)-6,9alfa-epoksi-11alfa,15-dihidroksiprosta-5,13-dienoat
Ovaj enzim konvertuje prostaglandin H2 u prostaglandin I2 (prostaciklin).
Reference
[уреди | уреди извор]- ^ DeWitt, D.L. & Smith, W.L. (1983). „Purification of prostacyclin synthase from bovine aorta by immunoaffinity chromatography. Evidence that the enzyme is a hemoprotein”. J. Biol. Chem. 258: 3285—3293. PMID 6338016.
- ^ Ullrich, V., Castle, L. and Weber, P. (1981). „Spectral evidence for the cytochrome P450 nature of prostacyclin synthetase”. Biochem. Pharmacol. 30: 2033—2036. PMID 7023490.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Prostaglandin-I+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
