27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza
| 27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.167 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
27S pre-rRNK (guanozin2922-2'-O)-metiltransferaza (EC 2.1.1.167, Spb1p (gen), YCL054W (gen)) je enzim sa sistematskim imenom S-adenozil-L-metionin:27S pre-rRNK (guanozin2922-2'-O-)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + guanozin2922 u 27S pre-rRNK S-adenozil-L-homocistein + 2'-O-metilguanozin2922 u 27S pre-rRNK
Spb1p je za mesto specifična 2'-O-riboza RNK metiltransferaza, koja katalizuje formiranje 2'-O-metilguanozina2922, univerzalno konzerviranje pozicije katalutičkog centera ribozoma koji je esencijalan za translaciju.
Reference
[уреди | уреди извор]- ^ Lapeyre, B. & Purushothaman, S.K. (2004). „Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage”. Mol. Cell. 16: 663—669. PMID 15546625.
- ^ Bonnerot, C., Pintard, L. and Lutfalla, G. (2003). „Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2′-O-ribose methylation of a conserved rRNA position in yeast”. Mol. Cell. 12: 1309—1315. PMID 14636587.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- 27S+pre-rRNA+(guanosine2922-2'-O)-methyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)
