Timidilat sintaza
| Timidilat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Timidilat sintaza dimer, Human | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.45 | ||||||||
| CAS broj | 9031-61-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Timidilat sintaza (EC 2.1.1.45, dTMP sintaza, timidilatna sintetaza, metilintetrahidrofolat:dUMP C-metiltransferaza, TMP sintetaza) je enzim sa sistematskim imenom 5,10-metilintetrahidrofolat:dUMP C-metiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 5,10-metilintetrahidrofolat + dUMP dihidrofolat + dTMP
Reference
[уреди | уреди извор]- ^ Blakley, R.L. (1963). „The biosynthesis of thymidylic acid. IV. Further studies on thymidylate synthase”. J. Biol. Chem. 238: 2113—2118.
- ^ Lockshin, A., Moran, R.G. and Danenberg, P.V. (1979). „Thymidylate synthetase purified to homogeneity from human leukemic cells”. Proc. Natl. Acad. Sci. USA. 76: 750—754. PMID 34155.
- ^ Slavik, K. & Slavikova, V. (1980). „Purification of thymidylate synthetase from enzyme-poor sources by affinity chromatography”. Methods Enzymol. 66: 709—723. PMID 6990200.
- ^ Wahba, A.J. & Friedkin, M. (1962). „The enzymatic synthesis of thymidylate. I. Early steps in the purification of thymidylate synthetase of Escherichia coli”. J. Biol. Chem. 237: 3794—3801. PMID 13998281.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Thymidylate+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
