SARS koronavirusna glavna proteinaza
| SARS koronavirusna glavna proteinaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.22.69 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
SARS koronavirusna glavna proteinaza (EC 3.4.22.69, 3cLpro, 3C-slična proteaza, koronavirusna 3C-like proteaza, Mpro, SARS 3C-slična proteaza, SARS koronavirusna 3CL proteaza, SARS koronavirusna glavna peptidaza, SARS-CoV 3CLpro enzim, SARS-CoV glavna proteaza, SARS-CoV Mpro, glavna proteaza koronavirusnog jakog akutnog respiratornog sindroma) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Najreaktivniji supstrati su peptidi TSAVLQ-SGFRK-NH2 i SGVTFQ-GKFKK. Oni korespondiju mestima samo presecanja SARS 3C-sličnih proteinaza. Postoji preferencija za supstrate sa Gln u P1 poziciji i Leu u P2 poziciji
Glavna proteaza SARS koronavirusa je ključni enzim u obradi replikaznih poliproteina SARS koronavirusa.
Reference
[уреди | уреди извор]- ^ Goetz, D.H., Choe, Y., Hansell, E., Chen, Y.T., McDowell, M., Jonsson, C.B., Roush, W.R., McKerrow, J. and Craik, C.S. (2007). „Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus”. Biochemistry. 46: 8744—8752. PMID 17605471.
- ^ Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J. and Lai, L. (2004). „Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase”. J. Biol. Chem. 279: 1637—1642. PMID 14561748.
- ^ Akaji, K., Konno, H., Onozuka, M., Makino, A., Saito, H. and Nosaka, K. (2008). „Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant”. Bioorg. Med. Chem. 16: 9400—9408. PMID 18845442.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- SARS+coronavirus+main+proteinase на US National Library of Medicine Medical Subject Headings (MeSH)
