Srebro sulfadiazin

Srebro sulfadiazin
Klinički podaci
Prodajno ime	Dermazin, Flamazine, Sildaflo, Silvadene
Drugs.com	sulfadiazine.html Monografija
Način primene	topikalno
Identifikatori
CAS broj	22199-08-2
ATC kod	D06BA01 (WHO)
PubChem	CID 441244
DrugBank	DB05245
ChemSpider	390017
ChEBI	CHEBI:9142
ChEMBL	CHEMBL1200766
Hemijski podaci
Formula	C10H9AgN4O2S
Molarna masa	357,137
	SMILES [Ag+].NC1=CC=C(C=C1)S(=O)(=O)[N-]C1=NC=CC=N1; ;
	InChI InChI=1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1 ; Key:UEJSSZHHYBHCEL-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	285 °C (545 °F)

Srebro sulfadiazin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 357,137 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	1
Broj rotacionih veza	3
Particioni koeficijent^[6] (ALogP)	0,4
Rastvorljivost^[7] (logS, log(mol/L))	-1,4
Polarna površina^[8] (PSA, Å²)	145,6

Reference

^ Fox CL Jr, Modak SM. „Mechanism of silver sulfadiazine action on burn wound infections”. Antimicrob Agents Chemother. 5 (6): 582—8. јун 1974. PMID 15825409. .
^ Russell, A. D.; Hugo, W. B. (1994). „Antimicrobial activity and action of silver”. Progress in Medicinal Chemistry. 1994 (31): 351—70. PMID 8029478. doi:10.1016/s0079-6468(08)70024-9.
^ Percival SL, Bowler PG, Russell D. „Bacterial resistance to silver in wound care”. Journal of Hospital Infection. 60 (1): 1—7. мај 2005. PMID 15823649. .
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Silver sulfadiazine

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Fox CL Jr, Modak SM. „Mechanism of silver sulfadiazine action on burn wound infections”. Antimicrob Agents Chemother. 5 (6): 582—8. јун 1974. PMID 15825409. .

[2] Russell, A. D.; Hugo, W. B. (1994). „Antimicrobial activity and action of silver”. Progress in Medicinal Chemistry. 1994 (31): 351—70. PMID 8029478. doi:10.1016/s0079-6468(08)70024-9.

[3] Percival SL, Bowler PG, Russell D. „Bacterial resistance to silver in wound care”. Journal of Hospital Infection. 60 (1): 1—7. мај 2005. PMID 15823649. .

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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