Trifunkcioni purinski biosintetički protein adenozin-3

Fosforibozilglicinamid formiltransferaza‎‎, fosforibozilglicinamid sintetaza, fosforibozilaminoimidazol sintetaza
Fosforibozilglicinamid formiltransferaza‎‎, fosforibozilglicinamid sintetaza, fosforibozilaminoimidazol sintetaza
	PDB prikaz baziran na 1rbm.
Dostupne strukture
	1MEJ, 1MEN, 1MEO, 1NJS, 1RBM, 1RBQ, 1RBY, 1RBZ, 1RC0, 1RC1, 1ZLX, 1ZLY, 2QK4, 2V9Y
Identifikatori
Simboli	GART; AIRS; GARS; GARTF; PAIS; PGFT; PRGS
Vanjski ID	OMIM: 138440 MGI: 95654 HomoloGene: 637 GeneCards: GART Gene
EC broj	6.3.3.1, 6.3.4.13 2.1.2.2, 6.3.3.1, 6.3.4.13
Ontologija gena
Molekularna funkcija	• aktivnost fosforibozilamin-glicinske ligaze; • aktivnost fosforibozilformilglicinamidinske ciklo-ligaze; • aktivnost fosforibozilglicinamidne formiltransferaze; • ATP vezivanje;
Celularna komponenta	• citozol;
Biološki proces	• purinski nukleobazni metabolički proces; • 'de novo' IMP biosintetički proces; • purinski nukleobazni biosintetički proces;
Ortolozi
Vrsta	Čovek
Entrez	2618
Ensembl	ENSG00000159131
UniProt	P22102
RefSeq (mRNA)	NM_000819
RefSeq (protein)	NP_000810
Lokacija (UCSC)	Chr 21:; 34.88 - 34.92 Mb
PubMed pretraga	[1]

Trifunkcioni purinski biosintetički protein adenozin-3 je enzim koji je kod ljudi kodiran GART genom.^[1]

Ovaj protein je trofunkcionalni polipeptid. On deluje kao fosforibozilglicinamid formiltransferaza (EC 6.3.4.13), fosforibozilglicinamidna sintetaza (EC 6.3.3.1), fosforibozilaminoimidazolna sintetaza (EC 2.1.2.2), koji je neophodan za de novo purinsku biosintezu.

Reference

^ Gnirke A, Barnes TS, Patterson D, Schild D, Featherstone T, Olson MV (1991). „Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes”. EMBO J. 10 (7): 1629—34. PMC 452831 . PMID 2050105.

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