U-plasminogeni aktivator
| U-plasminogeni aktivator | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 3.4.21.73 | ||||||||
| CAS broj | 9039-53-6 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
U-plasminogeni aktivator (EC 3.4.21.73, urokinaza, urinarni plazminogenski aktivator, ćelijski plazminogenski aktivator, urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, dvolančani urokinazni-tip plazminogenskog aktivatora, urokinazni plazminogenski aktivator, uPA, u-PA, abokinaza, urinarna esteraza A) je enzim.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Specifično razlaganje Arg-Val veze u plasminogenu čime se formira plazmin
Ovaj enzim se formira iz neaktivnog prekurzora posredstvom plazmina ili kalikreina plazme.
Reference
[уреди | уреди извор]- ^ Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L. (1981). „Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates”. Methods Enzymol. 80: 341—361. PMID 6210826.
- ^ Loskutoff, D.J. & Schleef, R.R. (1988). „Plasminogen activators and their inhibitors”. Methods Enzymol. 163: 293—302. PMID 3148826.
- ^ Saksela, O. & Rifkin, D.B. (1988). „Cell-associated plasminogen activation: regulation and physiological functions”. Annu. Rev. Cell Biol. 4: 93—126. PMID 3143380.
- ^ Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. Ур.: Handin, R.I., Lux, S.E. and Stossel, J.P. Blood: Principles and Practice of Hematology (2nd изд.). Philadelphia: J.B.Lippincott Company. стр. —.
- ^ Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D. (1990). „Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Glu)”. J. Biol. Chem. 265: 5232—5236. PMID 1969415.
Литература
[уреди | уреди извор]- Collen, D., Lijnen, H. R. and Verstraete, M. (1990). „The fibrinolytic system and its disorders”. Ур.: Handin, R.I., Lux, S.E. and Stossel, J.P. Blood: Principles and Practice of Hematology (2nd изд.). Philadelphia: J.B.Lippincott Company. стр. —.
Spoljašnje veze
[уреди | уреди извор]- U-plasminogen+activator на US National Library of Medicine Medical Subject Headings (MeSH)
