UK-414,495

UK-414,495
IUPAC ime
	(R)-2-({1-[(5-etil-1,3,4-tiadiazol-2-il)karbamoil]ciklopentil}metil)valerinska kiselina
Identifikatori
CAS broj	337962-93-3
ATC kod	none
PubChem	CID 9949799
Hemijski podaci
Formula	C16H25N3O3S
Molarna masa	339,45 g·mol−1
	SMILES CCc1nnc(s1)NC(=O)C2(CC(C(O)=O)CCC)CCCC2; ;
	InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 ; Key:FWXXCSISWQQOGS-LLVKDONJSA-N ;

UK-414,495 je lek koji je razvila kompanija Pfizer za tretman poremećaja ženskog seksualnog nadražaja.^[1] UK-414,495 deluje kao potentan i selektivan inhibitor enzima neutralna endopeptidaza, čija normalna funkcija je razlaganje neuropeptida VIP. Konsekventno povećanje VIP aktivnosti menja protok krvi u genitalnom regionu, što dovodi do povećanja lubrikacije i mišične relaksacije.^[2]^[3]^[4]

Reference

^ 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010
^ Armer R, Warne P, Witherington J (2006). „Recent disclosures of clinical drug candidates”. Drug News & Perspectives. 19 (1): 65—72. PMID 16550257. ISSN 0214-0934
^ Angulo J. (2010). „Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?”. British Journal of Pharmacology. 160: 48. doi:10.1111/j.1476-5381.2010.00693.x.
^ Wayman C.; Baxter D.; Turner L.; Van Der Graaf P.; Naylor A. (2010). „UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit”. British Journal of Pharmacology. 160 (1): 51—59. PMC 2860206 . PMID 20412068. doi:10.1111/j.1476-5381.2010.00691.x.

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[1] 'Female Viagra' will help women increase their sexual arousal. Daily Mail Online 14th April 2010

[pmid16550257-2] Armer R, Warne P, Witherington J (2006). „Recent disclosures of clinical drug candidates”. Drug News & Perspectives. 19 (1): 65—72. PMID 16550257. ISSN 0214-0934

[3] Angulo J. (2010). „Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder?”. British Journal of Pharmacology. 160: 48. doi:10.1111/j.1476-5381.2010.00693.x.

[4] Wayman C.; Baxter D.; Turner L.; Van Der Graaf P.; Naylor A. (2010). „UK-414,495, a selective inhibitor of neutral endopeptidase, potentiates pelvic nerve-stimulated increases in female genital blood flow in the anaesthetized rabbit”. British Journal of Pharmacology. 160 (1): 51—59. PMC 2860206 . PMID 20412068. doi:10.1111/j.1476-5381.2010.00691.x.

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