Zopiklon

Zopiklon
Klinički podaci
Prodajno ime	Amoban, Amovane, Imovance, Imovane
Drugs.com	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	5 h
Identifikatori
CAS broj	43200-80-2
ATC kod	N05CF01 (WHO)
PubChem	CID 5735
DrugBank	DB01198
ChemSpider	5533
ChEBI	CHEBI:32315
ChEMBL	CHEMBL135400
Hemijski podaci
Formula	C17H17ClN6O3
Molarna masa	388,808
	SMILES CN1CCN(CC1)C(=O)OC1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1; ;
	InChI InChI=1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3 ; Key:GBBSUAFBMRNDJC-UHFFFAOYSA-N ;
Fizički podaci
Tačka topljenja	178 °C (352 °F)

Zopiklon je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 388,808 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	7
Broj donora vodonika	0
Broj rotacionih veza	3
Particioni koeficijent^[8] (ALogP)	1,4
Rastvorljivost^[9] (logS, log(mol/L))	-2,2
Polarna površina^[10] (PSA, Å²)	91,8

Reference

^ Liu HJ, Sato K, Shih HC, Shibuya T, Kawamoto H, Kitagawa H (март 1985). „Pharmacologic studies of the central action of zopiclone: effects on locomotor activity and brain monoamines in rats”. Int J Clin Pharmacol Ther Toxicol. 23 (3): 121—8. PMID 2581904. .
^ Sato K, Hong YL, Yang MS, Shibuya T, Kawamoto H, Kitagawa H (април 1985). „Pharmacologic studies of central actions of zopiclone: influence on brain monoamines in rats under stressful condition”. Int J Clin Pharmacol Ther Toxicol. 23 (4): 204—10. PMID 2860074. .
^ Dundar Y, Dodd S, Strobl J, Boland A, Dickson R, Walley T (јул 2004). „Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis”. 19 (5): 305—22. PMID 15252823. .
^ Blanchard JC, Julou L (март 1983). „Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum”. Journal of Neurochemistry. 40 (3): 601—7. PMID 6298365. .
^ Julou, L.; Bardone, M. C.; Blanchard, J. C.; Garret, C.; Stutzmann, J. M. (1983). „Pharmacological studies on zopiclone”. Pharmacology. 27 (2): 46—58. PMID 6142468. doi:10.1159/000137911.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Zopiclone

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Liu HJ, Sato K, Shih HC, Shibuya T, Kawamoto H, Kitagawa H (март 1985). „Pharmacologic studies of the central action of zopiclone: effects on locomotor activity and brain monoamines in rats”. Int J Clin Pharmacol Ther Toxicol. 23 (3): 121—8. PMID 2581904. .

[2] Sato K, Hong YL, Yang MS, Shibuya T, Kawamoto H, Kitagawa H (април 1985). „Pharmacologic studies of central actions of zopiclone: influence on brain monoamines in rats under stressful condition”. Int J Clin Pharmacol Ther Toxicol. 23 (4): 204—10. PMID 2860074. .

[3] Dundar Y, Dodd S, Strobl J, Boland A, Dickson R, Walley T (јул 2004). „Comparative efficacy of newer hypnotic drugs for the short-term management of insomnia: a systematic review and meta-analysis”. 19 (5): 305—22. PMID 15252823. .

[4] Blanchard JC, Julou L (март 1983). „Suriclone: a new cyclopyrrolone derivative recognizing receptors labeled by benzodiazepines in rat hippocampus and cerebellum”. Journal of Neurochemistry. 40 (3): 601—7. PMID 6298365. .

[5] Julou, L.; Bardone, M. C.; Blanchard, J. C.; Garret, C.; Stutzmann, J. M. (1983). „Pharmacological studies on zopiclone”. Pharmacology. 27 (2): 46—58. PMID 6142468. doi:10.1159/000137911.

[6] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[7] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[8] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[9] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[10] Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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