G_s alfa podjedinica

GNAS complex locus
GNAS complex locus
Identifikatori
Simbol	GNAS
Alt. simboli	GNAS1
Entrez	2778
HUGO	4392
OMIM	139320
RefSeq	NM_000516
UniProt	Q5JWF2
Ostali podaci
Lokus	Hromozom 20 q13.2-13.3

G_s alfa podjedinica (ili Gs protein) je heterotrimerna G proteinska podjedinica koja aktivira cAMP-zavisni put aktivirajući adenilat ciklazu.^[1]^[2]

Receptori

G protein-spregnuti receptori koji se sprežu sa ovom vrstom G-proteina su:

5-HT receptorski tipovi 5-HT₄ i 5-HT₇
ACTH receptor
Adenozinski receptorski tipovi A_2a i A_2b
Arginin vazopresinski receptor 2
β-adrenergički receptorski tipovi β₁, β₂ i β₃
Kalcitoninski receptor
Kalcitoninskom genu srodni peptidni receptor
Kortikotropin-oslobađajući hormonski receptor
Dopaminski receptor D₁-slična familija (D₁ i D₅)
FSH-receptor
Receptor gastričnog inhibitornog polipeptida
Glukagonski receptor
Histaminski H₂ receptor
Luteinizirajući hormon/horiogonadotropin receptor
Melanokortinski receptor
Receptor paratiroidnog hormona 1
Prostaglandinski receptorski tipovi D₂ i I₂
Sekretinski receptor
Tirotropinski receptor

Function

Generalna funkcija G_s je da aktivira adenilat ciklazu, koja proizvodi cAMP, koji aktivira cAMP-zavisnu proteinsku kinazu.

G_s omogućava jedan korak u prenosu signala. Do amplifikacije signala dolazi zato što receptor aktivira više G_s proteina.^[3] Međutim, svaki G_s protein aktivira samo jedan molekul adenilat ciklaze.^[3]

Vidi još

Sistem sekundarnih glasnika

Spoljašnje veze

G(s)alpha на US National Library of Medicine Medical Subject Headings (MeSH)
GNAS+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

Референце

^ Mattera R; Graziano MP; Yatani A; et al. (1989). „Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. Science. 243 (4892): 804—7. PMID 2536957.
^ „Gs GTP-Binding Protein alpha Subunits - G(s)alpha Summary Report | CureHunter”.
^ ^а ^б Purves (2007). Neuroscience, 4th Edition. Sinauer Associates Inc. стр. 155. ISBN 9780878936977.

Литература

Purves (2007). Neuroscience, 4th Edition. Sinauer Associates Inc. стр. 155. ISBN 9780878936977.

[pmid2536957-1] Mattera R; Graziano MP; Yatani A; et al. (1989). „Splice variants of the alpha subunit of the G protein Gs activate both adenylyl cyclase and calcium channels”. Science. 243 (4892): 804—7. PMID 2536957.

[urlGs_GTP-Binding_Protein_alpha_Subunits_-_G(s)alpha_Summary_Report_|_CureHunter-2] „Gs GTP-Binding Protein alpha Subunits - G(s)alpha Summary Report | CureHunter”.

[neuro155-3] а ^б Purves (2007). Neuroscience, 4th Edition. Sinauer Associates Inc. стр. 155. ISBN 9780878936977.

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[2]

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