Метионин синтаза
| Metionin sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifikatori | |||||||||
| EC broj | 2.1.1.13 | ||||||||
| CAS broj | 9033-23-2 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Metionin sintaza (EC 2.1.1.13, 5-metiltetrahidrofolat-homocisteinska S-metiltransferaza, 5-metiltetrahidrofolat-homocisteinska transmetilaza, N-metiltetrahidrofolat:L-homocisteinska metiltransferaza, N5-metiltetrahidrofolatna metiltransferaza, N5-metiltetrahidrofolat-homocistein kobalaminska metiltransferaza, N5-metiltetrahidrofolni-homocistein vitamin B12 transmetilaza, B12 N5-metiltetrahidrofolat homocisteinska metiltransferaza, metiltetrahidrofolat-homocistein vitamin B12 metiltransferaza, tetrahidrofolatna metiltransferaza, tetrahidropteroilglutamatna metiltransferaza, tetrahidropteroilglutaminska metiltransferaza, vitamin B12 metiltransferaza, kobalamin-zavisna metioninska sintaza, metioninska sintaza (kobalamin-zavisna), METH) je enzim sa sistematskim imenom 5-metiltetrahidrofolat:L-homocistein S-metiltransferaza.[1][2][3][4][5][6][7][8][9] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-metiltetrahidrofolat + L-homocistein tetrahidrofolat + L-metionin
Ovaj enzim sadrži cink i kobamid.
Reference
[уреди | уреди извор]- ^ Burton, E.G. & Sakami, W. (1969). „The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants”. Biochem. Biophys. Res. Commun. 36: 228—234. PMID 5799642.
- ^ Foster, M.A., Dilworth, M.J. and Woods, D.D. (1964). „Cobalamin and the synthesis of methionine by Escherichia coli”. Nature. 201: 39—42. PMID 14085561.
- ^ Guest, J.R., Friedman, S., Foster, M.A., Tejerina, G. and Woods, D.D. (1964). „Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli”. Biochem. J. 92: 497—504. PMID 5319972.
- ^ Loughlin, R.E., Elford, H.L. and Buchanan, J.M. (1964). „Enzymatic synthesis of the methyl group of methionine. VII. Isolation of a cobalamin-containing transmethylase (5-methyltetrahydro-folate-homocysteine) from mammalian liver”. J. Biol. Chem. 239: 2888—2895. PMID 14216440.
- ^ Taylor, R.T. (1971). „Escherichia coli B N 5 -methyltetrahydrofolate-homocysteine cobalamin methyltransferase: gel-filtration behavior of apoenzyme and holoenzymes”. Biochim. Biophys. Acta. 242: 355—364. PMID 4946148.
- ^ Jarrett, J.T., Huang, S. and Matthews, R.G. (1998). „Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin”. Biochemistry. 37: 5372—5382. PMID 9548919.
- ^ Peariso, K., Goulding, C.W., Huang, S., Matthews, R.G. and Penner-Hahn, J.E. (1998). „Characterization of the zinc binding site in methionine synthase enzymes of Escherichia coli: The role of zinc in the methylation of homocysteine”. J. Am. Chem. Soc. 120: 8410—8416.
- ^ Hall, D.A., Jordan-Starck, T.C., Loo, R.O., Ludwig, M.L. and Matthews, R.G. (2000). „Interaction of flavodoxin with cobalamin-dependent methionine synthase”. Biochemistry. 39: 10711—10719. PMID 10978155.
- ^ Bandarian, V., Pattridge, K.A., Lennon, B.W., Huddler, D.P., Matthews, R.G. and Ludwig, M.L. (2002). „Domain alternation switches B12-dependent methionine synthase to the activation conformation”. Nat. Struct. Biol. 9: 53—56. PMID 11731805.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[уреди | уреди извор]- Methionine+synthase на US National Library of Medicine Medical Subject Headings (MeSH)
