Урацил/тимин дехидрогеназа
| Uracil/timin dehidrogenaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 1.17.99.4 | ||||||||
| CAS broj | 9029-00-9 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Uracil/timin dehidrogenaza (EC 1.17.99.4, uracil oksidaza, uracil-timin oksidaza) je enzim sa sistematskim imenom uracil:akceptor oksidoreduktaza.[1][2][3][4][5] Ovaj enzim katalizuje sledeću hemijsku reakciju
- (1) uracil + H2O + akceptor barbiturat + redukovani akceptor
- (2) timin + H2O + akceptor 5-metilbarbiturat + redukovani akceptor
Ovaj enzim formira deo oksidativnog puta degradacije pirimidina kod nekih mikroorganizama, zajedno sa EC 3.5.2.1 (barbiturazom) i EC 3.5.1.95 (N-malonilurejskom hidrolazom).
Reference
[уреди | уреди извор]- ^ Hayaishi, O. & Kornberg, A. (1952). „Metabolism of cytosine, thymine, uracil, and barbituric acid by bacterial enzymes”. J. Biol. Chem. 197: 717—723. PMID 12981104.
- ^ Wang, T.P. & Lampen, J.O. (1952). „Metabolism of pyrimidines by a soil bacterium”. J. Biol. Chem. 194: 775—783. PMID 14927671.
- ^ Wang, T.P. & Lampen, J.O. (1952). „Uracil oxidase and the isolation of barbituric acid from uracil oxidation”. J. Biol. Chem. 194: 785—791. PMID 14927672.
- ^ Lara, F.J.S. (1952). „On the decomposition of pyrimidines by bacteria. II. Studies with cell-free enzyme preparations”. J. Bacteriol. 64: 279—285. PMID 14955523.
- ^ Soong, C.L., Ogawa, J. and Shimizu, S. (2001). „Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase”. Biochem. Biophys. Res. Commun. 286: 222—226. PMID 11485332.
Literatura
[уреди | уреди извор]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[уреди | уреди извор]- Uracil/thymine+dehydrogenase на US National Library of Medicine Medical Subject Headings (MeSH)
