16S rRNK (citidin1409-2'-O)-metiltransferaza
| 16S rRNK (citidin1409-2'-O)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.227 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
16S rRNK (citidin1409-2'-O)-metiltransferaza (EC 2.1.1.227, TlyA (nespecifična)) je enzim sa sistematskim imenom S-adenozil-L-metionin:16S rRNK (citidin1409-2'-O)-metiltransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + citidin1409 u 16S rRNK S-adenozil-L-homocistein + 2'-O-metilcitidin1409 u 16S rRNK
Bifunkcionalni enzim iz Mycobakterija tuberculosis 2'-O-metiliše citidin1409 u heliksu 44 u 16S rRNK i citidin1920 u heliksu 69 u 23S rRNK (cf. EC 2.1.1.226, 23S rRNK (citidin1920-2'-O)-metiltransferaza).
Reference
[uredi | uredi izvor]- ^ Johansen, S.K., Maus, C.E., Plikaytis, B.B. and Douthwaite, S. (2006). „Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs”. Mol. Cell. 23: 173—182. PMID 16857584.
- ^ Maus, C.E., Plikaytis, B.B. and Shinnick, T.M. (2005). „Mutation of tlyA confers capreomycin resistance in Mycobacterium tuberculosis”. Antimicrob. Agents Chemother. 49: 571—577. PMID 15673735.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[uredi | uredi izvor]- 16S+rRNA+(cytidine1409-2'-O)-methyltransferase na US National Library of Medicine Medical Subject Headings (MeSH)
