Galaktozilksilozilprotein 3-b-galaktoziltransferaza
| Galaktozilksilozilprotein 3-b-galaktoziltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.4.1.134 | ||||||||
| CAS broj | 56626-19-8&title= 56626-21-2, 56626-19-8 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Galaktozilksilozilprotein 3-b-galaktoziltransferaza (EC 2.4.1.134, galaktoziltransferaza II, uridin difosfogalaktoza-galaktozilksilozna galaktoziltransferaza, UDP-galaktoza:4-beta-D-galaktozil-O-beta-D-ksilozilprotein 3-beta-D-galaktoziltransferaza) je enzim sa sistematskim imenom UDP-alfa-D-galaktoza:4-beta-D-galaktozil-O-beta-D-ksilosilprotein 3-beta-D-galaktoziltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- UDP-alfa-D-galaktoza + 4-beta-D-galaktozil-O-beta-D-ksilozil-[protein] UDP + 3-beta-D-galaktozil-4-beta-D-galaktozil-O-beta-D-ksilozil-[protein]
Ovaj enzim učestvuje u biosintezi veznog regiona glikozaminoglikanskih lanaca tokom proteoglikanske biosinteze (hondroitin, dermatan i heparan sulfati). Za njegov rad je neophodan Mn2+.
Reference
[uredi | uredi izvor]- ^ Robinson, J.A. & Robinson, H.C. (1985). „Initiation of chondroitin sulphate synthesis by β-D-galactosides. Substrates for galactosyltransferase II”. Biochem. J. 227: 805—814. PMID 3924029.
- ^ Schwartz, N.B. & Roden, L. (1975). „Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltransferase”. J. Biol. Chem. 250: 5200—5207. PMID 1150655.
- ^ Bai, X., Zhou, D., Brown, J.R., Crawford, B.E., Hennet, T. and Esko, J.D. (2001). „Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the β1,3-galactosyltransferase family (β3GalT6)”. J. Biol. Chem. 276: 48189—48195. PMID 11551958.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- William P. Jencks (1987). Catalysis in Chemistry and Enzymology. Dover Publications. ISBN 0486654605.
Spoljašnje veze
[uredi | uredi izvor]- Galactosylxylosylprotein+3-beta-galactosyltransferase na US National Library of Medicine Medical Subject Headings (MeSH)
