Jararhagin
Appearance
Jararhagin | |||||||||
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Identifikatori | |||||||||
EC broj | 3.4.24.73 | ||||||||
CAS broj | 160477-79-2 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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Jararhagin (EC 3.4.24.73, HF2-proteinaza, JF1) je enzim.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- Hidroliza -His10-Leu-, -Ala14-Leu-, -Tyr16-Leu- i -Phe24-Phe- veza u insulinskom B lancu
Ova hemoragička endopeptidaza je prisutna u venumu zmije Bothrops jararaca.
Reference[uredi | uredi izvor]
- ^ Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ur.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111—121.
- ^ Assakura, M.T., Reichl, A.P. and Mandelbaum, F.R. (1986). „Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)”. Toxicon. 24: 943—946. PMID 3810664.
- ^ Paine, M.J.I., Desmond, H.P., Theakston, R.D.G. and Crampton, J.M. (1992). „Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family”. J. Biol. Chem. 267: 22869—22876. PMID 1385408.
Literatura[uredi | uredi izvor]
- Mandelbaum, F.R., Reichl, A.P. and Assakura, M.T. (1976). „Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca”. Ur.: Ohsaka, A., Hayashi, K. and Sawai, Y. Animal, Plant and Microbial Toxins. New York: Plenum Press. str. 111—121.
Spoljašnje veze[uredi | uredi izvor]
- Jararhagin na US National Library of Medicine Medical Subject Headings (MeSH)