TRNK (adenin58-N1)-metiltransferaza
| tRNK (adenin58-N1)-metiltransferaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.1.1.220 | ||||||||
| Baze podataka | |||||||||
| IntEnz | IntEnz pregled | ||||||||
| BRENDA | BRENDA pristup | ||||||||
| ExPASy | NiceZyme pregled | ||||||||
| KEGG | KEGG pristup | ||||||||
| MetaCyc | metabolički put | ||||||||
| PRIAM | profil | ||||||||
| Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
tRNK (adenin58-N1)-metiltransferaza (EC 2.1.1.220, tRNK m1A58 metiltransferaza, tRNK (m1A58) metiltransferaza, TrmI, tRNK (m1A58) MTaza, Rv2118cp, Gcd10p-Gcd14p, Trm61p-Trm6p) je enzim sa sistematskim imenom S-adenozil-L-metionin:tRNK (adenin58-N1)-metiltransferaza.[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju
- S-adenozil-L-metionin + adenin58 u tRNK S-adenozil-L-homocistein + N1-metiladenin58 u tRNK
Ovaj enzim specifično metiluje adenin58 u tRNK. Metilacija A58 je kritična za održavanje stabilnosti inicijatora tRNKMet kod kvasca.
Reference
[uredi | uredi izvor]- ^ Droogmans, L., Roovers, M., Bujnicki, J.M., Tricot, C., Hartsch, T., Stalon, V. and Grosjean, H. (2003). „Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures”. Nucleic Acids Res. 31: 2148—2156. PMID 12682365.
- ^ Varshney, U., Ramesh, V., Madabushi, A., Gaur, R., Subramanya, H.S. and RajBhandary, U.L. (2004). „Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase”. Nucleic Acids Res. 32: 1018—1027. PMID 14960715.
- ^ Anderson, J., Phan, L. and Hinnebusch, A.G. (2000). „The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae”. Proc. Natl. Acad. Sci. USA. 97: 5173—5178. PMID 10779558.
Literatura
[uredi | uredi izvor]- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze
[uredi | uredi izvor]- TRNA+(adenine58-N1)-methyltransferase na US National Library of Medicine Medical Subject Headings (MeSH)
