A-N-acetilneuraminat a-2,8-sijaliltransferaza
Изглед
A-N-acetilneuraminat a-2,8-sijaliltransferaza | |||||||||
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Identifikatori | |||||||||
EC broj | 2.4.99.8 | ||||||||
CAS broj | 67339-00-8 | ||||||||
Baze podataka | |||||||||
IntEnz | IntEnz pregled | ||||||||
BRENDA | BRENDA pristup | ||||||||
ExPASy | NiceZyme pregled | ||||||||
KEGG | KEGG pristup | ||||||||
MetaCyc | metabolički put | ||||||||
PRIAM | profil | ||||||||
Strukture PBP | RCSB PDB PDBe PDBj PDBsum | ||||||||
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A-N-acetilneuraminat a-2,8-sijaliltransferaza (EC 2.4.99.8, citidin monofosfoacetilneuraminat-gangliozid GM3, alfa-2,8-sijaliltransferaza, gangliozid GD3 sintaza, gangliozid GD3 sintetaza sijaliltransferaza, CMP-NeuAc:LM1(alfa2-8) sijaliltranferaza, GD3 sintaza, SAT-2) je enzim sa sistematskim imenom CMP-N-acetilneuraminat:alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozid alfa-(2->8)-N-acetilneuraminiltransferaza.[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- CMP-N-acetilneuraminat + alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R CMP + alfa-N-acetilneuraminil-(2->8)-alfa-N-acetilneuraminil-(2->3)-beta-D-galaktozil-R
Gangliozidi mogu da deluju kao akceptori.
Reference[уреди | уреди извор]
- ^ Eppler, M.C., Morré, J.D. and Keenan, T.W. (1980). „Ganglioside biosynthesis in rat liver: alteration of sialyltransferase activities by nucleotides”. Biochim. Biophys. Acta. 619: 332—343. PMID 7407217.
- ^ Higashi, H., Basu, M. and Basu, S. (1985). „Biosynthesis in vitro of disialosylneolactotetraosylceramide by a solubilized sialyltransferase from embryonic chicken brain”. J. Biol. Chem. 260: 824—828. PMID 3838172.
- ^ McCoy, R.D., Vimr, E.R. and Troy, F.A. (1985). „CMP-NeuNAc:poly-α-2,8-sialosyl sialyltransferase and the biosynthesis of polysialosyl units in neural cell adhesion molecules”. J. Biol. Chem. 260: 12695—12699. PMID 4044605.
- ^ Yohe, H.C. and Yu, R.K. In vitro biosynthesis of an isomer of brain trisialoganglioside, GT (1980). „1a”. J. Biol. Chem. 255: 608—613. PMID 6766128.
Literatura[уреди | уреди извор]
- Nicholas C. Price; Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third изд.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 изд.). Wiley-Interscience. ISBN 0471205036.
- Branden C; Tooze J. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 изд.). Wiley Classics Library. ISBN 0471303097.
Spoljašnje veze[уреди | уреди извор]
- Alpha-N-acetylneuraminate+alpha-2,8-sialyltransferase на US National Library of Medicine Medical Subject Headings (MeSH)